SynthesisFrontiers in oncology2024
Meta-analysis of the diagnostic value of exosomal microRNAs in renal cell carcinoma.
Synthesis in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Circulating Tumor Function: A Systems Biology Framework for Liquid Biopsy in Genitourinary Cancers.Genes · 2026Review
- Targeting miRNAs in renal cell carcinoma: emerging therapeutic strategies.International journal of clinical oncology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: This meta-analysis aims to evaluate the potential of exosomal microRNAs(Exo-miRs) as diagnostic biomarkers for renal cell carcinoma(RCC). Methods: Clinical studies reporting the use of Exo-miRs in the diagnosis of RCC were retrieved from PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and Chinese Biomedical Literature Database (SinoMed). After relevant data were screened and extracted, the quality of the included studies was assessed using the QUADAS-2 tool. The Meta-disc (version 1.4) software was used to analyze the heterogeneity of threshold/non-threshold effects in the included studies. The Stata MP (version 16.0) software was used to calculate sensitivity(Sen), specificity(Spe), positive likelihood ratio(+LR), negative likelihood ratio(-LR), area under the curve(AUC), diagnostic odds ratio(DOR), and publication bias. Results: A total of 11 studies were included in this meta-analysis. Spearman correlation coefficient was 0.319 ( Conclusion: The expression of Exo-miRs plays an important role in the diagnosis of RCC. However, owing to the limited number of included studies and heterogeneity among them, further clinical research is necessary to verify the findings of this meta-analysis. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023445956.
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