Evidence map›Paper›PMID 39558921›Full record

ArticleBrain & spine2024

Rare primary dedifferentiated liposarcoma of the thoracic spine: A case report and literature review.

Christine Kögler, Bernhard W Ullrich, Klaus D Schaser, Alexander C Disch, Gunther O Hofmann, Felix Göhre, Christian Mawrin, Matthias Vogt

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain & spine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christine KöglerDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.
Bernhard W UllrichDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.
Klaus D SchaserUniversity Center of Orthopaedics, Trauma and Plastic Surgery, National Center for Tumor Diseases Dresden (NCT/UCC), Sarcoma Center, University Comprehensive Spine Center, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Alexander C DischUniversity Center of Orthopaedics, Trauma and Plastic Surgery, National Center for Tumor Diseases Dresden (NCT/UCC), Sarcoma Center, University Comprehensive Spine Center, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Gunther O HofmannDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.
Felix GöhreDepartment of Neurosurgery, BG Hospital Bergmannstrost Halle, Merseburger Str. 165, 06112, Halle, Saale, Germany.
Christian MawrinInstitute of Neuropathology, University Hospital Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Matthias VogtDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Primary dedifferentiated liposarcomas of the spine mark a rare tumor entity. Research question and case description: We present a rare case of a primary dedifferentiated liposarcoma of the thoracic spine. A 36-year-old previously completely healthy woman presented with a sudden ascending paresthesia of both legs, persistently increasing over the course of two days before initial presentation. Case report: Computed tomography and magnetic resonance imaging revealed an expansively growing tumor mass extending from T5 to T6 and absolutely compressing the dural sac and spinal cord. The patient's neurological function completely recovered after emergency posterior decompression via laminectomy with intralesional tumor debulking. The tumor was histologically classified as primary grade 2 dedifferentiated liposarcoma (DDLPS) of the spine and after referral to a sarcoma center, the patient was treated with three courses of polychemotherapy (doxorubicin plus ifosfamide). Chemotherapy was followed by aggressive resection by en-bloc spondylectomy in cooperation with a spine tumor center. Subsequently, the patient also underwent radiation therapy. Results: The patient still undergoes structured tumor aftercare and is tumor- and metastasis-free 53 months after tumor resection. Discussion and conclusion: DDLPS rarely occur in the spine, with definitive resection of the tumor being the treatment of choice. Surgery should be accompanied by other (radio-) oncological treatment options in cases where only subtotal resection is possible. Also, referral of patients with primary sarcomas of the spine to specialized sarcoma centers is essential, so they can be provided with individual treatment options and structured interdisciplinary aftercare, that ensure the best possible outcome.

Indexed as

Dedifferentiated liposarcomaEn-bloc spondylectomyLiposarcomaPrimary spinal tumorThoracic spine

Identifiers

PMID39558921
PMCPMC11570891

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.