Evidence map›Paper›PMID 39558897›Full record

ArticleJournal of neurotrauma2025

Genetic Differences Modify Anesthetic Preconditioning of Traumatic Brain Injury in Drosophila.

Dena Johnson-Schlitz, Amanda R Seidl, Zachariah P G Olufs, Wen Huang, David A Wassarman, Misha Perouansky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dena Johnson-SchlitzDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA.
Amanda R SeidlDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA.
Zachariah P G OlufsDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA.
Wen HuangDepartment of Animal Science, Michigan State University, East Lansing, Michigan, USA.
David A WassarmanDepartment of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Misha PerouanskyDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA.

Funding

Genetic variation and evolution of translational control in DrosophilaR01GM138423 · NIGMS · MICHIGAN STATE UNIVERSITY · PI HUANG, WEN · 2020 to 2024
$1.7M
NIGMS NIH HHS R01 GM138423
6 · The paper itself

Abstract

Pre-clinical vertebrate models of traumatic brain injury (TBI) routinely use anesthetics for animal welfare; however, humans experience TBI without anesthetics. Therefore, translation of findings from vertebrate models to humans hinges on understanding how anesthetics influence cellular and molecular events that lead to secondary injuries following TBI. To investigate the effects of anesthetics on TBI outcomes, we used an invertebrate

Indexed as

Anesthetics, InhalationBrain Injuries, TraumaticIsofluraneAnimalsDisease Models, AnimalDrosophila melanogasterGenome-Wide Association StudySevofluraneAnesthetics, InhalationIsofluraneSevofluraneanestheticsDrosophila melanogastergenome-wide association studyisofluranesevofluranetraumatic brain injury

Identifiers

PMID39558897
PMCPMC12677224

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.