Evidence map›Paper›PMID 39558646›Full record

ArticleKidney research and clinical practice2026

Circulating osteoprotegerin and progression of coronary artery calcification in patients with chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD).

Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Soo Wan Kim

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Article in Kidney research and clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sang Heon SuhDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Tae Ryom OhDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Hong Sang ChoiDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Chang Seong KimDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Eun Hui BaeDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Seong Kwon MaDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Kook-Hwan OhDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Tae-Hyun YooDepartment of Internal Medicine and Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Soo Wan KimDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea. skimw@chonnam.ac.kr.

Funding

Korea Disease Control and Prevention Agency 2011 E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019E320101, 2019E320102, and 2022-11-007National Research Foundation of Korea RS-2023-00217317National Research Foundation of Korea RS-2023-00278258
6 · The paper itself

Abstract

backgroundCoronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression.

methodsA total of 1,130 patients with CKD stage 1 to predialysis 5 were divided into quartiles according to serum OPG levels (Q1 to Q4). The coronary artery calcium score (CACS) was assessed at baseline and at the 4-year follow-up visit. CAC progression was defined as an increase in the CACS of more than 200 Agatston units over 4 years.

resultsSerum OPG levels were positively correlated with the CACS at baseline (R = 0.240, p < 0.001) and at the 4-year follow-up visit (R = 0.280, p < 0.001) as well as with changes in the CACS for 4 years (R = 0.270, p < 0.001) based on scatter plot analysis. Binary logistic regression analysis demonstrated that the risk of CAC progression was significantly increased in Q4 compared with Q1 (adjusted odds ratio, 3.706; 95% confidence interval, 1.154-11.902). Penalized spline curve analysis revealed a linear association between serum OPG levels and the risk of CAC progression.

conclusionAn increase in circulating OPG levels was associated with the risk of CAC progression in patients with predialysis CKD.

Indexed as

BiomarkersChronic renal insufficiencyCoronary artery diseaseOsteoprotegerin

Identifiers

PMID39558646
PMCPMC13346898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.