Evidence map›Paper›PMID 39558533›Full record

ArticleJournal of surgical oncology2025

Brachytherapy for Soft Tissue Sarcoma: Maintaining Local Control While Minimizing Complications.

Julien Montreuil, Eric Kholodovsky, Moses Markowitz, Sergio Torralbas Fitz, Dominic Campano, Erik Geiger, Francis Hornicek, Brooke Crawford, Martin Keisch, H Thomas Temple

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julien MontreuilDepartment of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0000-0002-4893-7455
Eric KholodovskyUniversity of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0009-0005-5542-6564
Moses MarkowitzUniversity of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0000-0002-8315-654X
Sergio Torralbas FitzDepartment of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0000-0002-0348-2143
Dominic CampanoDepartment of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0000-0001-8397-4369
Erik GeigerDepartment of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Francis HornicekDepartment of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0000-0002-6916-8042
Brooke CrawfordDepartment of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Martin KeischCancer HealthCare Associates, Miami, Florida, USA.
H Thomas TempleDepartment of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0000-0001-7408-6271

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to assess the clinical and oncologic outcomes of high-dose brachytherapy (BRT) versus both preoperative and postoperative external beam radiation therapy (EBRT) in the setting of high-grade soft tissue sarcoma.

methodsThis is a retrospective cohort study of 144 patients treated surgically for soft tissue sarcoma at the same institution from 2010 to 2021. Patients treated for a soft tissue sarcoma with surgery and radiation therapy in the form of BRT, Neoadjuvant EBRT (Neo-EBRT) or adjuvant EBRT (AD-EBRT) were included.

results56 patients were treated with BRT, 42 with Neo-EBRT, and 46 with AD-EBRT. There was a greater incidence of grouped wound complications in Neo-EBRT with 50% compared to both BRT with 25% and AD-EBRT with 28.3% (p = 0.02). Univariate and multivariate analysis showed that there was an increased risk of wound complications with Neo-EBRT when compared to brachytherapy (p = 0.03 and p = 0.007, respectively). Univariate and multivariate analysis showed that there was no difference in risk of LR between treatment groups (p = 0.28).

conclusionBrachytherapy is a valuable treatment modality that offers clinical and logistical advantages when compared to the conventional Neo-EBRT in soft tissue sarcomas. Brachytherapy offers a lower risk of wound complications and a comparable local control. This manuscript presents decision-making strategies for determining the appropriate radiation modality for specific circumstances.

Indexed as

BrachytherapyPostoperative ComplicationsSarcomaSoft Tissue NeoplasmsAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoadjuvant TherapyRadiotherapy, AdjuvantRetrospective StudiesYoung Adultbrachytherapysoft tissue sarcomawound complications

Identifiers

PMID39558533
PMCPMC12120387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.