ArticleMicrobiome2024
The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish.
Article in Microbiome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cetobacterium somerae ZNN-1 promotes goblet cell differentiation through glutamine-mediated Notch signaling suppression.Journal of advanced research · 2026Article
- Optimization and application of probiotics complex for grouper based on dynamic model.World journal of microbiology & biotechnology · 2026Article
- Gut Microbiome of Aquatic Organisms: Role in Immunity Formation and Effects on Aquaculture Productivity.Microorganisms · 2026Review
- Effects of dietary chitosan oligosaccharide on juvenile grass carp: Insight from the intestinal microbiota and metabolism.Journal of fish biology · 2026Article
- Gut Microbiota Divergence Drives Aeromonas Hydrophila Resistance in Common Carp (Cyprinus carpio): Probiotic Role of Cetobacterium.Probiotics and antimicrobial proteins · 2026Article
- Modulatory effects of plant extract combinations on growth performance, hepato-intestinal homeostasis, intestinal microbiota, and Streptococcus agalactiae resistance in Acrossocheilus fasciatus.BMC veterinary research · 2026Article
- The microbiota-gut-immunity axis in teleost fish: dual regulatory mechanisms of viral infections and prospects for microbiome-based antiviral strategies.Fish physiology and biochemistry · 2026Review
- TiOInternational journal of molecular sciences · 2026Article
- Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction.Aging cell · 2026Article
- Vitamin KJournal of animal science and biotechnology · 2026Article
- Microbiota Composition Shaped by Seasonal Variation and Environmental Compartments Affects the Abundance of Antimicrobial-Resistant Bacteria in Indonesian Aquaculture.Environmental microbiology reports · 2026Article
- Gut T cell-microbiota crosstalk orchestrates antibacterial immunity and mucosal homeostasis in teleost.Microbiome · 2026Article
- The Role of Gut Microbiota in Fish Viral Infection: Mechanisms and Microbiota-Targeted Interventions.Aquaculture nutrition · 2026Review
- Extensive fecal cast production and growth of Vibrionaceae in heat-stressed Atlantic salmon post-smolts.Scientific reports · 2025Article
- Article
- Frog Density and Growth Stage of Rice Impact Paddy Field and Gut Microbial Communities in Rice-Frog Co-Cropping Models.Microorganisms · 2025Article
- Cetobacterium somerae-derived argininosuccinic acid promotes intestinal and liver ureagenesis to alleviate ammonia intoxication.Microbiome · 2025Article
- Article
- Absolute abundance unveils Basidiobolus as a cross-domain bridge indirectly bolstering gut microbiome homeostasis.The ISME journal · 2025Article
- Microbiome engineering to enhance disease resistance in aquaculture: current strategies and future directions.Frontiers in microbiology · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundEvidence has accumulated to demonstrate that intestinal microbiome can inhibit viral infection. However, our knowledge of the signaling pathways and identity of specific commensal microbes that mediate the antiviral response is limited. Zebrafish have emerged as a powerful animal model for study of vertebrate-microbiota interactions. Here, a rhabdoviral infection model in zebrafish allows us to investigate the modes of action of microbiome-mediated antiviral effect.
resultsWe observed that oral antibiotics-treated and germ-free zebrafish exhibited greater spring viremia of carp virus (SVCV) infection. Mechanistically, depletion of the intestinal microbiome alters TLR2-Myd88 signaling and blunts neutrophil response and type I interferon (IFN) antiviral innate immunity. Through 16S rRNA sequencing of the intestinal contents from control and antibiotic(s)-treated fish, we identified a single commensal bacterial species, Cetobacterium somerae, that can restore the TLR2- and neutrophil-dependent type I IFN response to restrict SVCV infection in gnotobiotic zebrafish. Furthermore, we found that C. somerae exopolysaccharides (CsEPS) was the effector molecule that engaged TLR2 to mediate the type I IFN-dependent antiviral function.
conclusionsTogether, our results suggest a conserved role of intestinal microbiome in regulating type I IFN antiviral response among vertebrates and reveal that the intestinal microbiome inhibits viral infection through a CsEPS-TLR2-type I IFN signaling axis in zebrafish. Video Abstract.
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