Evidence map›Paper›PMID 39558366›Full record

Trial reportRadiation oncology (London, England)2024

First-in-human trial using mixed-reality visualization for patient setup during breast or chest wall radiotherapy.

Perry B Johnson, Julie Bradley, Samsun Lampotang, Amanda Jackson, David Lizdas, William Johnson, Eric Brooks, Raymond B Mailhot Vega, Nancy Mendenhall

Registry-linked trialAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiation oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05178927 (UFPTI 2105-BR05), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05178927 nacompletednot on this map

UFPTI 2105-BR05: Improving Breast Radiotherapy Setup and Delivery Using Mixed-Reality Visualization

TypeinterventionalSponsorUniversity of FloridaRan2022 to 2023Enrolled27ConditionsBreast CancerArmsHoloLens v2
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Perry B JohnsonUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA. PBJohnson@floridaproton.org.
Julie BradleyUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
Samsun LampotangUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
Amanda JacksonUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
David LizdasUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
William JohnsonUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
Eric BrooksUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
Raymond B Mailhot VegaUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
Nancy MendenhallUniversity of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.

Funding

Florida Breast Cancer Foundation AGR DTD 06-25-2021
6 · The paper itself

Abstract

backgroundThe purpose of this study is to assess the feasibility of mixed-reality (MixR) visualization for patient setup in breast and chest wall radiotherapy (RT) by performing a first-in-human clinical trial comparing MixR with a 3-point alignment.

methodsIRB approval was granted for a study incorporating MixR during the setup process for patients undergoing proton (n = 10) or photon (n = 8) RT to the breast or chest wall. For each patient, MixR was utilized for five fractions and compared against another five fractions using 3-point alignment. During fractions with MixR, the patient was aligned by at least one therapist wearing a HoloLens 2 device who was able to guide the process by simultaneously and directly viewing the patient and a hologram of the patient's surface derived from their simulation CT scan. Alignment accuracy was quantified with cone-beam CT (CBCT) for photon treatments and CBCT plus kV/kV imaging for proton treatments. Registration time was tracked throughout the setup process as well as the amount of image guidance (IGRT) utilized for final alignment.

resultsIn the proton cohort, the mean 3D shift was 0.96 cm using 3-point alignment and 1.18 cm using MixR. An equivalence test indicated that the difference in registration accuracy between the two techniques was less than 0.5 cm. In the photon cohort, the mean 3D shift was 1.18 cm using 3-point alignment and 1.00 cm using MixR. An equivalence test indicated that the difference in registration accuracy was less than 0.3 cm. Minor differences were seen in registration time and the amount of IGRT utilization.

conclusionsMixR for patient setup for breast cancer RT is possible at the level of accuracy and efficiency provided by a 3-point alignment. Further developments in marker tracking, feedback, and a better understanding of the perceptual challenges of MixR are needed to achieve a similar level of accuracy as provided by modern surface-guided radiotherapy (SGRT) systems.

trial registrationClinicalTrials.gov, UFHPTI 2015-BR05: Improving Breast Radiotherapy Setup and Delivery Using Mixed-Reality Visualization, NCT05178927.

Indexed as

Breast NeoplasmsProton TherapyRadiotherapy Planning, Computer-AssistedThoracic WallCone-Beam Computed TomographyFeasibility StudiesFemaleHumansPatient PositioningRadiotherapy DosageRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedBreast radiotherapyHoloLens 2Mixed-realitySurface-guided radiotherapy

Identifiers

PMID39558366
PMCPMC11574990

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.