Evidence map›Paper›PMID 39558234›Full record

SynthesisBMC geriatrics2024

Impact of multicomponent exercise and nutritional supplement interventions for improving physical frailty in community-dwelling older adults: a systematic review and meta-analysis.

Wachiranun Sirikul, Nida Buawangpong, Kanokporn Pinyopornpanish, Penprapa Siviroj

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07637890 (Designing a Multicomponent Intervention for Improving Frailty. A Pilot Study in the Basque Country), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07637890 nacompletednot on this map

Designing a Multicomponent Intervention for Improving Frailty. A Pilot Study in the Basque Country

TypeinterventionalSponsorBiogipuzkoa Health Research InstituteRan2024 to 2025Enrolled32ConditionsFrailtyArmsMulti-component intervention: physical exercise, polypharmacy review and nutritional care
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. The relationship between frailty and depression in Chinese elderly prostate cancer patients following radical surgery: the mediating effect of sleep disturbances.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wachiranun SirikulDepartment of Community Medicine, Faculty of Medicine Chiang, Mai University, Chiang Mai, 50200, Thailand.
Nida BuawangpongDepartment of Family Medicine, Faculty of Medicine Chiang, Mai University, Chiang Mai, 50200, Thailand.
Kanokporn PinyopornpanishDepartment of Family Medicine, Faculty of Medicine Chiang, Mai University, Chiang Mai, 50200, Thailand.
Penprapa SivirojDepartment of Community Medicine, Faculty of Medicine Chiang, Mai University, Chiang Mai, 50200, Thailand. penprapa.s@cmu.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the efficacy of both multicomponent exercise and nutritional interventions on frailty by conducting a systematic review and meta-analysis to examine changes in frailty incidence.

designA systematic review and meta-analysis. ELIGIBLE CRITERIA: The included studies were limited to original controlled trials focused on frailty interventions in older adults aged 65 years and over. The studies involved only participants with specific diseases, and those recovering from surgery or being hospitalized were excluded. INFORMATION SOURCES: A systematic search was performed on three databases: PUBMED, EMBASE, and Cumulative Index to Nursing and Allied Health, with the latest search in October 2024. Three authors independently extracted the data using a standardized data collection form. Relative risks were used as a summary measure. Pooled-effect estimates of each outcome were calculated by the random-effects meta-analysis.

resultsAfter searching three databases, 5327 records were identified. After removing duplicates and screening the titles and abstracts, 19 multicomponent exercise studies and 7 nutritional intervention studies were eligible. In a pooled analysis of 18 multicomponent exercise RCTs, including a total of 3457 older adults, the multicomponent exercises showed a clinically significant reduction in frailty risk by relative change 55% times (95% CI 45% to 67%, p value < 0.001). The subgroup analysis of combinations of macronutrients and micronutrients also demonstrated statistically significant decrease in frailty risk by relative change 28% times (95% CI 11% to 72%, p value = 0.008).

conclusionMulticomponent exercises can effectively improve physical frailty, regardless of the duration and types of the activities, whereas the efficacy of nutritional supplements remains unclear. Personalized multicomponent approaches that incorporate both exercises and nutritional supplements have promised to enhance effectiveness in reducing frailty, thus warranting further investigation.

trial registrationThe study was registered on 12 September 2022, under PROSPERO registration number CRD42022357357.

Indexed as

Dietary SupplementsFrail ElderlyFrailtyIndependent LivingAgedAged, 80 and overExerciseExercise TherapyHumansFrailtyMulticomponent exerciseNutritional interventionsOlder adults

Identifiers

PMID39558234
PMCPMC11571505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.