Evidence map›Paper›PMID 39558197›Full record

Observational studyActa paediatrica (Oslo, Norway : 1992)2025

Therapeutic hypothermia success for hypoxic-ischaemic encephalopathy in Latin America: Eight-year experience in EpicLatino Neonatal Network.

Carlos Fajardo, Marco Belzu, Manuel Bernal Benitez, Ángela Hoyos, Rubén Hernández Patiño, Luis Monterrosa, Carolina Villegas, EpicLatino Neonatal Network

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlos FajardoPediatrics, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-7353-0385
Marco BelzuEpicLatino Neonatal Network, Calgary, Alberta, Canada.
Manuel Bernal BenitezEpicLatino Neonatal Network, Calgary, Alberta, Canada.
Ángela HoyosEpicLatino Neonatal Network, Calgary, Alberta, Canada.ORCID 0000-0002-5403-3268
Rubén Hernández PatiñoEpicLatino Neonatal Network, Calgary, Alberta, Canada.
Luis MonterrosaEpicLatino Neonatal Network, Calgary, Alberta, Canada.
Carolina VillegasEpicLatino Neonatal Network, Calgary, Alberta, Canada.
EpicLatino Neonatal Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimA study reported that therapeutic hypothermia (TH) did not reduce the combined prognosis of mortality and disability at 18 months, in low- and middle-income countries for patients with hypoxic ischaemic encephalopathy (HIE) who received TH, suggesting its no implementation in these regions. We described characteristics, mortality, and neurological response before and after the use of TH in newborns with HIE within the EpicLatino Neonatal Network (ENN) and described the population of infants with HIE treated and not treated with TH.

methodsData were collected from 2015 to 2022 for patients with HIE. Mortality rates and Sarnat scores were compared before and after TH. The Wilcoxon Signed-Rank Test was used for comparisons.

resultsIn this observational study 518 neonates of our total population of 26 970, had HIE (1.92%) of whom 150 underwent TH. Ten out of 21 neonatal intensive care units (NICUs) provided TH. The Wilcoxon Signed Rank Test for 138 cases with complete data showed a significant difference.

conclusionThe findings support the benefits of TH in HIE within this cohort. TH should not be withheld solely due to the economic status of the country. A strict patient selection and TH protocol are essential.

Indexed as

Hypothermia, InducedHypoxia-Ischemia, BrainFemaleHumansInfant, NewbornLatin AmericaMaleTreatment OutcomeEpicLatino Neonatal Networkhypoxic ischaemic encephalopathyinfant newbornLatin Americalow‐ or middle‐income countriesSarnat scoretherapeutic hypothermia

Identifiers

PMID39558197
PMCPMC11976138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.