ArticleScientific reports2024
A low-cost perfusion heating system for slice electrophysiology.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level.Biophysical journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temperature-critical applications, such as patch-clamp electrophysiology, require constant perfusion at a fixed temperature. However, maintaining perfusate at a specific temperature throughout various applications requires heaters or coolers with integrated feedback systems, which has historically increased complexity and cost. This makes such systems prohibitively expensive in research environments with lower funding rates, particularly in developing countries. We developed a custom temperature control system that relies on off-the-shelf components and few custom parts, which can be easily produced with common tools. Our system can be built for less than $30 and maintains a set perfusate temperature within 0.4 °C while introducing negligible electrical interference. Using this system, we demonstrate that Striatal Medium Spiny Neurons exhibit increased membrane resistance, longer membrane time constants, lower firing rates, and increased rheobase current at room temperature compared to physiological temperature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.