Evidence map›Paper›PMID 39557921›Full record

ArticleScientific reports2024

4-Furanylvinylquinoline derivative as a new scaffold for the design of oxidative stress initiator and glucose transporter inhibitor drugs.

Michał Kuczak, Wioleta Cieślik, Robert Musioł, Anna Mrozek-Wilczkiewicz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michał KuczakA. Chelkowski Institute of Physics, University of Silesia in Katowice, 75 Pulku Piechoty 1a, Chorzow, 41- 500, Poland.
Wioleta CieślikInstitute of Chemistry, University of Silesia in Katowice, Szkolna 9, Katowice, 40-006, Poland.
Robert MusiołInstitute of Chemistry, University of Silesia in Katowice, Szkolna 9, Katowice, 40-006, Poland.
Anna Mrozek-WilczkiewiczA. Chelkowski Institute of Physics, University of Silesia in Katowice, 75 Pulku Piechoty 1a, Chorzow, 41- 500, Poland. anna.mrozek-wilczkiewicz@us.edu.pl.

Funding

Narodowe Centrum Nauki 2018/31/B/NZ7/02Narodowe Centrum Nauki 2020/39/O/NZ5/02342
6 · The paper itself

Abstract

In the present study, a detailed analysis of the effect of a substitution at the C4 position of the quinoline ring by styryl or furanylvinyl substituents on the structure-antitumour activity relationship was conducted. After analysing a library of derivatives from the styrylquinoline and furanylvinylquinoline groups, we selected the most active (IC

Indexed as

ApoptosisOxidative StressQuinolinesTumor Suppressor Protein p53Antineoplastic AgentsCell Cycle CheckpointsCell Line, TumorDrug DesignGlucose Transporter Type 1HCT116 CellsHumansStructure-Activity RelationshipAntineoplastic AgentsGlucose Transporter Type 1QuinolinesTP53 protein, humanTumor Suppressor Protein p53ApoptosisCell cycle inhibitionFuranylvinylquinolinesGLUT inhibitorOxidative stressp53 mutationWarburg effect

Identifiers

PMID39557921
PMCPMC11574108

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.