Evidence map›Paper›PMID 39557919›Full record

ArticleScientific reports2024

New insights into the role of the CHI3L2 protein in invasive ductal breast carcinoma.

Agnieszka Rusak, Ewa Kątnik, Tomasz Górnicki, Christina Schmuttermaier, Krzysztof Kujawa, Aleksandra Piotrowska, Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Andrzej Wojnar, Piotr Dzięgiel and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Agnieszka RusakDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego St. 6a, 50-368, Wroclaw, Poland. agnieszka.rusak@umw.edu.pl.ORCID http://orcid.org/0000-0001-9587-0575
Ewa KątnikDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego St. 6a, 50-368, Wroclaw, Poland.ORCID http://orcid.org/0000-0002-4618-9668
Tomasz GórnickiDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego St. 6a, 50-368, Wroclaw, Poland.ORCID http://orcid.org/0000-0002-7277-8036
Christina SchmuttermaierInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl Street 13-17, 68167, Mannheim, Germany.
Krzysztof KujawaStatistical Analysis Centre, Wroclaw Medical University, K. Marcinkowskiego 2-6 St, 50-368, Wroclaw, Poland.ORCID http://orcid.org/0000-0003-2812-4702
Aleksandra PiotrowskaDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego St. 6a, 50-368, Wroclaw, Poland.ORCID http://orcid.org/0000-0003-4093-7386
Katarzyna Ratajczak-WielgomasDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego St. 6a, 50-368, Wroclaw, Poland.ORCID http://orcid.org/0000-0001-6175-2204
Alicja KmiecikDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego St. 6a, 50-368, Wroclaw, Poland.ORCID http://orcid.org/0000-0002-6498-717X
Andrzej WojnarDepartment of Preclinical Sciences, Pharmacology and Diagnostics, Faculty of Medicine, Wroclaw University of Science and Technology, Hoene-Wronskiego 13 C St, 58-376, Wroclaw, Poland.ORCID http://orcid.org/0000-0002-9470-3190
Piotr DzięgielDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego St. 6a, 50-368, Wroclaw, Poland.ORCID http://orcid.org/0000-0002-8292-1385
Julia KzhyshkowskaInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl Street 13-17, 68167, Mannheim, Germany.ORCID http://orcid.org/0000-0003-0898-3075

Funding

National Science Center, Poland (NCN) 2021/05/X/NZ2/01698
6 · The paper itself

Abstract

Chitinase-like proteins have multiple biological functions that promote tumor growth, angiogenesis and metastasis. Expression of CHI3L2, which is similar in structure to CHI3L1, is detected in glioma cells and tumor-associated macrophages (TAMs) in glioma and breast cancer. However, its exact role remains unclear. We analyzed the expression of CHI3L2 in 74 invasive ductal breast carcinoma (IDC) tumors, breast cancer and macrophages cell cultures using immunohistochemistry, immunofluorescence, Western blot and PCR methods. Clinicopathologic data were included in the analysis. The results obtained show that CHI3L2 expression decreases with increasing degree of tumor grade and negative status of estrogen (ER) and progesterone receptors (PR). Furthermore, CHI3L2 is significantly and positively correlated with phosphorylation of STAT-3 and ERK1/2 signaling pathways, but negatively correlated with macrophage infiltration. CHI3L2 is expressed both in the cytoplasm of cancer cells and in macrophages and may regulate STAT-3 and ERK1/2 phosphorylation in breast cancer cell lines. Analysis of the clinicopathologic data revealed that CHI3L2 levels had no effect on patient survival. CHI3L2 expression may be specific for cancer cells in IDC and involved in cross-talk with the tumor microenvironment. Our study has shown that IDC cancer cells express the CHI3L2 protein, possibly indicating a novel function of this protein.

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastAdultAgedCell Line, TumorChitinase-3-Like Protein 1ChitinasesFemaleGene Expression Regulation, NeoplasticHumansMacrophagesMAP Kinase Signaling SystemMiddle AgedPhosphorylationSTAT3 Transcription FactorCHI3L2 protein, humanChitinase-3-Like Protein 1ChitinasesSTAT3 protein, humanSTAT3 Transcription FactorCHI3L1CHI3L2Chitinase-like proteinsERK1/2Invasive ductal breast carcinomaSTAT-3

Identifiers

PMID39557919
PMCPMC11574116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.