Evidence map›Paper›PMID 39557863›Full record

ArticleNature communications2024

IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells.

Olivier Fesneau, Kimberly A Samson, Wesley Rosales, Bretton Jones, Tarsem Moudgil, Bernard A Fox, Venkatesh Rajamanickam, Thomas Duhen

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Adipocyte-derived LTB4 programs human NKG2AJournal for immunotherapy of cancer · 2026
    Article
  3. Article
  4. The CD94/NKG2A-HLA-E Axis as a Target in Cancer Immunotherapy: A Critical Perspective.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  5. Clonal CD8Nature immunology · 2026
    Article
  6. Deriving genetic codes for molecular phenotypes from first principles.bioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olivier FesneauEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Kimberly A SamsonEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0000-0003-3779-4273
Wesley RosalesEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0000-0002-6381-9844
Bretton JonesEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Tarsem MoudgilEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Bernard A FoxEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0000-0002-4452-5947
Venkatesh RajamanickamEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0000-0001-6864-7589
Thomas DuhenEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA. thomas.duhen@providence.org.ORCID 0000-0002-3043-9116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blockade of NKG2A/HLA-E interaction is a promising strategy to unleash the anti-tumor response. Yet the role of NKG2A

Indexed as

CD8-Positive T-LymphocytesInterleukin-12NK Cell Lectin-Like Receptor Subfamily CAntigens, CDApyraseCell DifferentiationColorectal NeoplasmsHead and Neck NeoplasmsHLA-E AntigensHumansIntegrin alpha ChainsLymphocytes, Tumor-InfiltratingReceptors, Antigen, T-CellSquamous Cell Carcinoma of Head and NeckAntigens, CDApyraseENTPD1 protein, humanHLA-E AntigensIntegrin alpha ChainsInterleukin-12KLRC1 protein, humanNK Cell Lectin-Like Receptor Subfamily CReceptors, Antigen, T-Cell

Identifiers

PMID39557863
PMCPMC11574270

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.