Evidence map›Paper›PMID 39557776›Full record

ReviewMolecular diagnosis & therapy2025

Leveraging Multi-omics to Disentangle the Complexity of Ovarian Cancer.

Shijuan Lin, Lily L Nguyen, Alexandra McMellen, Michael S Leibowitz, Natalie Davidson, Daniel Spinosa, Benjamin G Bitler

Abstract readReview
In one paragraph

Review in Molecular diagnosis & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shijuan LinDivisions of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, MS 8613, Aurora, CO, 80045, USA.
Lily L NguyenDivisions of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, MS 8613, Aurora, CO, 80045, USA.
Alexandra McMellenCenter for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA.
Michael S LeibowitzCenter for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA.
Natalie DavidsonDivisions of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, MS 8613, Aurora, CO, 80045, USA.
Daniel SpinosaGynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Benjamin G BitlerDivisions of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, MS 8613, Aurora, CO, 80045, USA. Benjamin.Bitler@cuanschutz.edu.ORCID 0000-0002-5809-5271

Funding

Spatiotemporal Staging of the HIV-1 Preintegration complexR01AI170228 · NIAID · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2022 to 2026
$2.8M
Elucidating a novel WNT4 regulatory axis as a driver of gynecologic cancer health disparitiesR01CA285446 · NCI · UNIVERSITY OF COLORADO DENVER · PI Benjamin G Bitler, Matthew J Sikora · 2023 to 2026
$2.4M
Targeting Wnt signaling in therapy-resistant ovarian cancerR37CA261987 · NCI · UNIVERSITY OF COLORADO DENVER · PI Benjamin G Bitler · 2021 to 2026
$2.4M
Domain adaptation approaches to unify established and emerging sequencing technologiesR00HG012945 · NHGRI · UNIVERSITY OF COLORADO DENVER · PI Natalie Rose Davidson · 2024 to 2026
$747k
CSR NIH HHS R37CA261987Department of Defense OC170228Department of Defense OC200225Department of Defense OC200302NCI NIH HHS R01 CA285446NCI NIH HHS R37 CA261987NHGRI NIH HHS R00 HG012945NIAID NIH HHS R01 AI170228
6 · The paper itself

Abstract

To better understand ovarian cancer lethality and treatment resistance, sophisticated computational approaches are required that address the complexity of the tumor microenvironment, genomic heterogeneity, and tumor evolution. The ovarian cancer tumor ecosystem consists of multiple tumors and cell types that support disease growth and progression. Over the last two decades, there has been a revolution in -omic methodologies to broadly define components and essential processes within the tumor microenvironment, including transcriptomics, metabolomics, proteomics, genome sequencing, and single-cell analyses. While most of these technologies comprehensively characterize a single biological process, there is a need to understand the biological and clinical impact of integrating multiple -omics platforms. Overall, multi-omics is an intriguing analytic framework that can better approximate biological complexity; however, data aggregation and integration pipelines are not yet sufficient to reliably glean insights that affect clinical outcomes.

Indexed as

GenomicsMetabolomicsOvarian NeoplasmsProteomicsBiomarkers, TumorComputational BiologyFemaleHumansMultiomicsSingle-Cell AnalysisTranscriptomeTumor MicroenvironmentBiomarkers, Tumor

Identifiers

PMID39557776
PMCPMC12176028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.