Evidence map›Paper›PMID 39557729›Full record

ArticleDiscover oncology2024

Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study.

Abbas Shakoori, Asghar Hosseinzadeh, Nahid Nafisi, Ramesh Omranipour, Leyla Sahebi, Nazanin Hosseinkhan, Mohsen Ahmadi, Soudeh Ghafouri-Fard, Maryam Abtin

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Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Abbas ShakooriDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Asghar HosseinzadehDepartment of Biology Education, Farhangian University, Tehran, Iran.
Nahid NafisiSurgery Department, Rasoul Akram Hospital, Clinical Research Development Center (RCRDC), Iran University of Medical Sciences, Tehran, Iran.
Ramesh OmranipourBreast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.
Leyla SahebiMaternal, Fetal and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Nazanin HosseinkhanEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Mohsen AhmadiDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soudeh Ghafouri-FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. s.ghafourifard@sbmu.ac.ir.
Maryam AbtinDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. m.abtin.genetics@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to examine the importance of an lncRNA, namely LINC00852, in the pathogenesis of breast cancer. MATERIALS AND

methodsIn the current study, we used several online tools to examine the importance of LINC00852 in breast cancer. Then, we examined these findings in 50 pairs of breast cancer tissues and adjacent non-cancerous ones. We also re-evaluated the data of miR-145-5p signature from our recent study.

resultsWhile in silico tools revealed down-regulation of LINC00852 in breast cancer samples, expression assays showed significant up-regulation of this lncRNAs in breast cancer samples compared with matching control samples from Iranian patients. miR-145-5p was under-expressed in breast cancer samples compared with non-cancerous samples. LINC00852 could separate breast cancer tissues from adjacent non-malignant tissues with an AUC value of 0.7218 (P value < 0.001).

conclusionThe current study potentiates LINC00852/miR-145-5p axis as a possible contributor to the pathogenesis of breast cancer.

Indexed as

Breast cancerLINC00852miR-145-5p

Identifiers

PMID39557729
PMCPMC11574217

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.