Evidence map›Paper›PMID 39557688›Full record

ReviewIntensive care medicine2024

Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults.

Jenelle Badulak, Darryl Abrams, Andrew M Luks, Bishoy Zakhary, Steven A Conrad, Robert Bartlett, Graeme MacLaren, Leen Vercaemst, Roberto Lorusso, Lars Mikael Broman and 9 more

Erratum issuedAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Endovascular resuscitation: an expert practice review.Emergency medicine journal : EMJ · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. ECMO for patients needing surgery.Intensive care medicine · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Jenelle Badulak *Department of Emergency Medicine, University of Washington, Seattle, WA, USA. badulakj@uw.edu.ORCID 0000-0001-9024-1075
Darryl Abrams *Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Andrew M LuksDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA.
Bishoy ZakharyDivision of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA.
Steven A ConradDepartments of Medicine, Emergency Medicine, Pediatrics and Surgery, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.
Robert BartlettDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Graeme MacLarenCardiothoracic ICU, National University Hospital, Singapore, Singapore.
Leen VercaemstUniversity Hospital Gasthuisberg, Louvain, Belgium.
Roberto LorussoCardiothoracic Surgery Department, Heart and Vascular Center, Maastricht University Medical Center, Maastricht, Netherlands.
Lars Mikael BromanECMO Centre Karolinska, Karolinska University Hospital, Stockholm, Sweden.
Cara AgerstrandDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Susanna PriceRoyal Brompton Hospital, London, UK.
Alain CombesDepartment of Intensive Care Medicine, Sorbonne University, La Pitie-Salpetriere Hospital, Paris, France.
Giles PeekDivision of Cardiothoracic Surgery, University of Florida Shands Children's Hospital, Congenital Heart Center at University of Florida Health, Gainesville, FL, USA.
Eddy FanInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Kiran ShekarCritical Care Research Group, The Prince Charles Hospital, University of Queensland, Brisbane, QLD, Australia.
John FraserCritical Care Research Group, The Prince Charles Hospital, University of Queensland, Brisbane, QLD, Australia.
Daniel BrodieDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Extracorporeal Life Support Organization (ELSO)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When native blood flow through the aorta from the adult heart and lungs meets retrograde blood flow from an artificial heart and lung during venoarterial extracorporeal membrane oxygenation (VA-ECMO), the result is the creation of two separate circulations on either side of the blood flow mixing point. This phenomenon is known as dual circulation and is characterized by different content of oxygen and carbon dioxide between the circulations. There is currently a lack of clarity surrounding the nomenclature to describe this physiologic phenomenon in VA-ECMO and thus we endeavor to name and define these terms to facilitate clear communication and proper clinical management of these patients.

Indexed as

Extracorporeal Membrane OxygenationTerminology as TopicAdultCarbon DioxideHumansOxygenCarbon DioxideOxygenDifferential carbon dioxideDifferential oxygenationDual circulationExtracorporeal life supportExtracorporeal membrane oxygenationMixing point

Identifiers

PMID39557688
PMCPMC11588769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.