Evidence map›Paper›PMID 39557677›Full record

SynthesisCardiovascular and interventional radiology2025

A Meta-Analysis and Meta-Regression of Embolisation Outcomes of Pulmonary Arteriovenous Malformations.

Yousef Shahin, Cyrilkumaar Vijayakumar, Amarit Gill, Andrzej Lejawka, Steve Bennett, Rebecca Willis, Mustafa Abbas, Daniel Kusumawidjaja

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Do We Need Level I Evidence for a Well-Functioning Intervention?Cardiovascular and interventional radiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yousef ShahinSheffield Vascular Institute, Sheffield Teaching Hospitals, Sheffield, UK. yousef.shahin@nhs.net.ORCID http://orcid.org/0000-0001-7425-7798
Cyrilkumaar VijayakumarMedical School, University of Sheffield, Sheffield, UK.
Amarit GillDepartment of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK.
Andrzej LejawkaSheffield Vascular Institute, Sheffield Teaching Hospitals, Sheffield, UK.
Steve BennettDepartment of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK.
Rebecca WillisDepartment of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK.
Mustafa AbbasSheffield Vascular Institute, Sheffield Teaching Hospitals, Sheffield, UK.
Daniel KusumawidjajaSheffield Vascular Institute, Sheffield Teaching Hospitals, Sheffield, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEmbolisation is a widely utilised therapeutic intervention for pulmonary arteriovenous malformation (PAVM). We conducted a meta-analysis to evaluate outcomes of PAVM embolisation and factors associated with embolisation outcomes.

methodsMEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from 2000 to July 2022 on studies that assessed embolisation outcomes of PAVM. Immediate technical success rate defined as the complete occlusion of the PAVM at the time of embolisation and treatment success rate defined as ≥ 70% venous sac reduction on follow-up imaging were pooled from included studies with use of random effects proportion meta-analysis. Heterogeneity across studies was assessed with the I

resultsForty-four studies including 1865 patients (604 (32%) males, mean age (range) 45 (24-59) years, 1125 (60%) had hereditary haemorrhagic telangiectasia (HHT)) were included in the meta-analysis. Studies included a total of 4314 PAVMs of which 4047 (94%) were treated. Studies reported morphology of 3074 PAVMs (2519 (58%) simple and 555 (13%) complex). The pooled overall immediate technical success rate for PAVM embolisation was 99%, 95% CI (98-100%) and the treatment success rate was 86%, 95% CI (84-89%). Younger age (p = 0.041), simple PAVM (0.020), and embolisation using plugs (p = 0.001) were associated with higher treatment success. Feeding artery and sac embolisation (p = 0.021) and using coils (p = 0.001) were associated with lower treatment success. There was no significant difference in recanalisation rate between different embolisation agents (OR 0.64, 95% CI -0.09- 1.38).

conclusionThis meta-analysis shows that PAVM embolisation is safe and effective. Higher treatment success rates for PAVM embolisation can be achieved using plugs as the primary embolisation agent. Embolisation agent used had no effect on recanalisation rates.

Indexed as

Arteriovenous MalformationsEmbolization, TherapeuticPulmonary ArteryPulmonary VeinsAdultHumansMaleTreatment OutcomeEmbolisationMeta-analysisOutcomesPredictorsPulmonary arteriovenous malformation

Identifiers

PMID39557677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.