Evidence map›Paper›PMID 39557656›Full record

ArticleHistochemistry and cell biology2024

The amelioration effects of ankaferd blood stopper, platelet gel, and Momordica charantia on peripheral nerve injury in the rats: a stereological and ultrastructural study.

Gamze Altun, Mehmet Emin Önger, Stefano Geuna, Abubaker El Elhaj, Stefania Raimondo, Ömür Gülsüm Deniz, Suleyman Kaplan

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Article in Histochemistry and cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Gamze AltunDepartment of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye.
Mehmet Emin ÖngerDepartment of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye. mehmetemin.onger@gmail.com.
Stefano GeunaDepartment of Clinical and Biological Science, Faculty of Medicine, Neuroscience Institute of Cavalieri Ottolenghi, Turin University, Turin, Italy.
Abubaker El ElhajDepartment of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye.
Stefania RaimondoDepartment of Clinical and Biological Science, Faculty of Medicine, Neuroscience Institute of Cavalieri Ottolenghi, Turin University, Turin, Italy.
Ömür Gülsüm DenizDepartment of Histology and Embryology, Faculty of Medicine, Bolu Abant İzzet Baysal University, Bolu, Türkiye.
Suleyman KaplanDepartment of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye.

Funding

TUBITAK Abroad Research Scholarship Program (2214) and Ondokuz Mayıs University (). PYO. TIP. 1904.11.001
6 · The paper itself

Abstract

Peripheral nerve injuries are commonly encountered in clinical practice. Peripheral nerve injuries most commonly result in serious problems affecting quality of life. The present study is designed to research the possible neuroprotective effects of Ankaferd blood stopper (ABS), platelet-rich plasma (PRP), and Momordica charantia (MC) on regeneration using unbiased stereological techniques. In total, 30 female 8-10 week Sprague Dawley rats were randomly divided into five equal groups; control (CG), the group exposed to sciatic nerve resection (Gap) (CGG), additionally following the surgical process ABS, MC, and PRP were injected into collagen tube (ABSG, MCG, PRPG). Nucleator and fractionator methods were used to estimate the number of myelinated and unmyelinated axons, axon area, and myelin sheath thickness. Also, an electron microscopic evaluation was performed. Regarding the number of myelinated axons, significant increases were found in the ABSG, MCG, and PRPG compared with CG (p < 0.05). The protective effects of ABS, PRP, and MC on peripheral nerve regeneration in experimental models in rats were shown using electrophysiological and stereological assessment parameters.

Indexed as

Momordica charantiaPeripheral Nerve InjuriesPlant ExtractsRats, Sprague-DawleyAnimalsFemaleGelsNerve RegenerationPlatelet-Rich PlasmaRatsankaferd blood stopperGelsPlant ExtractsAnkaferd blood stopperAntioxidantMomordica charantiaNerve injuryPlasma-rich platelet

Identifiers

PMID39557656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.