Evidence map›Paper›PMID 39557641›Full record

SynthesisAesthetic plastic surgery2025

Minimizing Blood Loss Using Tranexamic Acid in Patients Undergoing Liposuction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Abdulaziz F Abumelha, Ibrahim R Halawani, Rakan Abu Alqam, Feryal Khalid Alali, Razan Omar Alsubhi, Haya AlMosained, Lama A Alkhwildi, Ibrahim Abdullah S Albalawi, Abdulaziz Alsuhaim, Yousef M Al Mashhrawi and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdulaziz F AbumelhaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Ibrahim R HalawaniCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Rakan Abu AlqamCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Feryal Khalid AlaliCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Razan Omar AlsubhiCollege of Medicine, Taibah University, Medina, Saudi Arabia.
Haya AlMosainedCollege of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia.
Lama A AlkhwildiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Ibrahim Abdullah S AlbalawiCollege of Medicine, Tabuk University, Tabuk, Saudi Arabia.
Abdulaziz AlsuhaimCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Yousef M Al MashhrawiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Anas BafailCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Nawaf AlohaidebKing Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia. Nawafplastic@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiposuction has become the most sought-after aesthetic surgery across the globe, increasing the demand for more developments in patient safety protocols. Evidence of the efficacy of tranexamic acid (TXA) in reducing intraoperative blood loss with minimal complications have led to its widespread applications across various surgical operations. However, the role and effectiveness of TXA in liposuction is not fully understood. Therefore, the purpose of this systematic review and meta-analysis is to investigate the effectiveness of TXA in minimizing intraoperative blood loss in patients undergoing liposuction.

methodsIn adherence to the preferred reporting items for systematic reviews and meta-analysis guidelines, a comprehensive search was conducted in multiple databases including, PubMed, Cochrane CENTRAL, and Web of Science. Only randomized controlled trials (RCTs) were included without time frame limitations. Our primary outcomes were hemoglobin levels, hematocrit levels, lipoaspirate volume, and associated complications.

resultsThis meta-analysis provides a comprehensive analysis of five RCTs published between 2021-2023, involving 334 patients. The pooled mean difference for postoperative hemoglobin levels was statistically significant in favor of local TXA administration (MD 0.54; P = 0.03; I

conclusionAlthough a statistically significant difference was seen in postoperative hemoglobin levels, it is imperative that the results are interpreted with caution, given the preliminary nature of the observed effect. Further large well-designed RCTs are required to solidify current TXA protocols and to provide comprehensive guidelines for its application in liposuction. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

Indexed as

Antifibrinolytic AgentsBlood Loss, SurgicalLipectomyTranexamic AcidFemaleHumansRandomized Controlled Trials as TopicTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidBlood lossHemostasisLiposuctionTranexamic acidTumescent liposuction

Identifiers

PMID39557641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.