Evidence map›Paper›PMID 39557450›Full record

SynthesisInternational wound journal2024

Local wound care management for pyoderma gangrenosum.

Adeeb Haroon, Jordan Gillespie, Jaclyn Roland-McGowan, Riyad N H Seervai, Lisa J Gould, Valentina Dini, Alex G Ortega-Loayza

Abstract readLetterSystematic Review
In one paragraph

Synthesis in International wound journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. The Changing Landscape of Clinical Research in Pyoderma Gangrenosum.The Journal of investigative dermatology · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adeeb HaroonDepartment of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-5779-6324
Jordan GillespieDepartment of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
Jaclyn Roland-McGowanDepartment of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
Riyad N H SeervaiDepartment of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
Lisa J GouldDepartment of Plastic Surgery, Weymouth, Massachusetts, USA.ORCID https://orcid.org/0000-0001-5167-4679
Valentina DiniDepartment of Dermatology, University of Pisa, Pisa, Italy.
Alex G Ortega-LoayzaDepartment of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyoderma gangrenosum (PG) is a rare, painful neutrophilic dermatosis characterized by rapidly progressing skin ulcers. Despite the importance of local wound care in managing PG, there is no consensus or evidence-based guidelines. This systematic review aimed to investigate local wound care strategies for PG. A comprehensive search of Embase, MEDLINE, and the Cochrane Library yielded 1213 references, from which 269 studies were included, covering 351 patients. The most reported treatment methods included sharp debridement (11%), topical corticosteroids (27%) and non-adherent dressings (12%). However, no clear correlation between these treatments and healing outcomes was found likely due to confounding factors such as varied wound sizes, superinfection and inconsistent reporting. Additionally, directed wound care regimens have not been able to show statistical significance for healing outcomes. Our study describes the current local wound care landscape and underscores a critical gap in the current literature regarding standardized treatment protocols for PG.

Indexed as

BandagesDebridementPyoderma GangrenosumWound HealingAdrenal Cortex HormonesAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedAdrenal Cortex Hormones

Identifiers

PMID39557450
PMCPMC11573439

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.