Evidence map›Paper›PMID 39557387›Full record

ArticleThe Journal of pediatrics2025

Sleep Disorders Five Years After Acute Provoked Neonatal Seizures.

Renée A Shellhaas, Linda S Franck, Betsy Pilon, Courtney J Wusthoff, Shavonne L Massey, Catherine J Chu, Janet S Soul, Monica E Lemmon, Adam L Numis, Julie S Sturza and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Renée A ShellhaasDepartment of Neurology, Washington University School of Medicine, St Louis, MO. Electronic address: rshellhaas@wustl.edu.
Linda S FranckDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, CA; Department of Family Health Care Nursing, University of California, San Francisco, CA.
Betsy PilonHope for HIE, West Bloomfield, MI.
Courtney J WusthoffDepartment of Neurology, University of California, Davis, Sacramento, CA.
Shavonne L MasseyDepartments of Neurology and Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Catherine J ChuDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Janet S SoulDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Monica E LemmonDepartments of Pediatrics and Population Health Sciences, Duke University, School of Medicine, Durham, NC.
Adam L NumisDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, CA; Department of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, CA.
Julie S SturzaDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI.
Cameron ThomasDivision of Neurology, Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Giulia M BenedettiDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI.
Stephanie M D RauDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI.
Tayyba AnwarDivision of Neurology, Children's National Hospital, Washington, DC.
Madison M BerlDivision of Neuropsychology, Children's National Hospital, Washington, DC.
Charles E McCullochDepartment of Epidemiology & Biostatistics University of California, San Francisco, CA.
Hannah C GlassDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, CA; Department of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, CA; Department of Epidemiology & Biostatistics University of California, San Francisco, CA.

Funding

Neonatal Seizure Registry Developmental Functional EValuation (NSR-DEV)R01NS111166 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY, SHELLHAAS, RENEE A. · 2020 to 2023
$4.6M
NINDS NIH HHS R01 NS111166
6 · The paper itself

Abstract

objectiveTo evaluate whether abnormal sleep is associated with adverse outcomes for children who survived acute provoked neonatal seizures, and their parents. STUDY

designThis 9-center study prospectively followed newborns with acute provoked seizures. When children reached age 5 years, parents completed the Children's Sleep Habits Questionnaire (CSHQ), the Pediatric Sleep Questionnaire-Sleep Related Breathing Disorders (PSQ-SRBD) subscale, the Vineland Adaptive Behavior Scales-3, and the Hospital Anxiety Depression Scale. Children were also assessed with the Wechsler Preschool and Primary Scale of Intelligence-IV (WPPSI-IV). Spearman correlations and multivariable analyses were used to evaluate risk factors for sleep problems.

resultsThe mean CSHQ score was 45 ± 7; 77 of 118 children (65%) had an abnormal score (above the healthy sleep threshold of 41). On the PSQ-SRBD, 32 of 119 children (27%) screened positive for sleep-disordered breathing (SDB). SDB symptoms were more common among children with cerebral palsy (42% with vs 22% without; P = .03) and epilepsy (54% with vs 24% without; P = .02). Children with lower scores on the Vineland-3 (rho = -0.25; P = .01) and WPPSI-IV (rho = -0.31; P = .004) at 5 years of age were more likely to have symptoms of SDB. Worse CSHQ and PSQ-SRBD scores were associated with higher parental anxiety (rho = 0.28 [P = .002] and rho = 0.34 [P = .0002], respectively) and depression scores on the Hospital Anxiety Depression Scale (rho = 0.16 [P = .08] and rho = 0.17 [P = .07], respectively).

conclusionsTwo-thirds of early school-aged survivors of acute provoked neonatal seizures had parent-reported sleep abnormalities and one-quarter screened positive for SDB. Early screening and effective treatment for sleep disorders could be an innovative, practice-changing approach to improve outcomes after neonatal seizures.

Indexed as

SeizuresSleep Wake DisordersChild, PreschoolFemaleFollow-Up StudiesHumansInfant, NewbornMaleProspective StudiesRisk FactorsSleep Apnea SyndromesSurveys and Questionnaires

Identifiers

PMID39557387
PMCPMC12377511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.