Evidence map›Paper›PMID 39557386›Full record

Trial reportThe Journal of pediatrics2025

Assessing Early Severity of Hypoxic-Ischemic Encephalopathy: The Role of Electroencephalogram Background in Addition to Sarnat Exam.

Marie-Coralie Cornet, Adam L Numis, Sarah E Monsell, Natalie H Chan, Fernando F Gonzalez, Bryan A Comstock, Sandra E Juul, Courtney J Wusthoff, Yvonne W Wu, Hannah C Glass

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marie-Coralie CornetDepartment of Pediatrics, University of California San Francisco, San Francisco, CA. Electronic address: Marie-Coralie.Cornet@ucsf.edu.
Adam L NumisDepartment of Neurology and the Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA.
Sarah E MonsellDepartment of Biostatistics, University of Washington, Seattle, WA.
Natalie H ChanDepartment of Pediatrics, University of California San Francisco, San Francisco, CA.
Fernando F GonzalezDepartment of Pediatrics, University of California San Francisco, San Francisco, CA.
Bryan A ComstockDepartment of Biostatistics, University of Washington, Seattle, WA.
Sandra E JuulDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA.
Courtney J WusthoffDepartment of Neurology, Stanford University, Palo Alto, CA.
Yvonne W WuDepartment of Pediatrics, University of California San Francisco, San Francisco, CA; Department of Neurology and the Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA.
Hannah C GlassDepartment of Pediatrics, University of California San Francisco, San Francisco, CA; Department of Neurology and the Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.

Funding

High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) DCCU01NS092553 · NINDS · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J · 2016 to 2020
$1.7M
HEAL - EEG - Neurophysiologic measures of Epo treatment for hypoxic-ischemic encephalopathy (HIE)R01NS104322 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY · 2018 to 2021
$1.5M
Maternal Chorioamnionitis and Hypoxic-Ischemic Encephalopathy: The MATCH StudyK23HD109684 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Marie Cornet · 2022 to 2026
$867k
NICHD NIH HHS K23 HD109684NINDS NIH HHS R01 NS104322NINDS NIH HHS U01 NS092553NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

objectiveTo assess the relationship between the Sarnat exam, early electroencephalogram (EEG) background, and death or neurodevelopmental impairment (NDI) at age 2 years among neonates with moderate to severe hypoxic-ischemic encephalopathy treated with therapeutic hypothermia. STUDY

designNeonates enrolled in the High-dose Erythropoietin for Asphyxia and Encephalopathy trial with EEG (n = 463) or amplitude-integrated electroencephalogram (n = 15) reports available on the first day after birth were included in this cohort study. A Sarnat exam was performed between 1 and 6 hours after birth, and neonates were classified into 3 groups of increasing severity based on the number of severe features (none, 1-2, or 3+). EEG background continuity was extracted from reports and categorized as normal, excessively discontinuous, or severely abnormal. The primary outcome was severe NDI or death at age 2.

resultsAmong 478 neonates with hypoxic-ischemic encephalopathy, EEG background continuity was normal in 186 (39%), excessively discontinuous in 171 (36%), and severely abnormal in 121 (25%). For each additional severe feature on the Sarnat exam, the risk of abnormal EEG background increased by 16% (relative risk 1.16 [95% CI 1.09-1.23]). Both the Sarnat exam and EEG background severity were associated with an increased risk of severe NDI or death. After adjusting for Sarnat exam severity, severe EEG background remained associated with severe NDI and death (relative risk 5.7 [95% CI 3.7-8.9]).

conclusionsThe early EEG background provides additional information beyond the Sarnat exam and could be an additional early marker when assessing the severity of HIE.

Indexed as

ElectroencephalographyHypoxia-Ischemia, BrainAsphyxia NeonatorumChild, PreschoolCohort StudiesErythropoietinFemaleHumansHypothermia, InducedInfant, NewbornMaleSeverity of Illness IndexErythropoietinbrainbrain injuryelectroencephalographyhypothermiahypoxia-ischemiainducedinfantneurodevelopment

Identifiers

PMID39557386
PMCPMC12227128

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.