Evidence map›Paper›PMID 39557279›Full record

ArticleExperimental eye research2025

Complement C3 knockout protects photoreceptors in the sodium iodate model.

Tan Wang, Ying Song, Brent A Bell, Brandon D Anderson, Timothy T Lee, Weihong Yu, Joshua L Dunaief

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tan WangDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Ying SongFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Brent A BellFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Brandon D AndersonFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Timothy T LeeFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Weihong YuDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. Electronic address: yuweihongpumch@163.com.
Joshua L DunaiefFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: jdunaief@pennmedicine.upenn.edu.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
Retinal Iron Transport in Health and DiseaseR01EY015240 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA L DUNAIEF · 2004 to 2026
$10.4M
RESEARCH ON NORMAL AND ABNORMAL MECHANISMS OF VISIONST32EY007035 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Diego Contreras, Jessica I.W. Morgan · 1985 to 2026
$4.9M
Development of Two Novel AMD Models for Evaluation of RPE Protection by the Novel Antioxidant D-DHAR01EY036292 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA L DUNAIEF · 2024 to 2026
$1.3M
Spectralis Tracking HRA-Optical Coherence Tomography 2 (OCT2): Advanced Ophthalmic Imaging for Small and Large Animal StudiesS10OD026860 · OD · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, JEAN · 2019 to 2019
$239k
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY015240NEI NIH HHS R01 EY036292NEI NIH HHS T32 EY007035NIGMS NIH HHS T32 GM008076NIH HHS S10 OD026860
6 · The paper itself

Abstract

Complement factor 3 (C3) has emerged as a primary therapeutic target in age-related macular degeneration (AMD) supported by genetic, histologic, and clinical trial evidence. Yet, the site(s) of action are unclear. The purpose of this study was to test the effect of C3 knockout on photoreceptors and retinal pigment epithelial cells (RPE) in the sodium iodate (NaIO

Indexed as

Complement C3Disease Models, AnimalElectroretinographyIodatesMice, Inbred C57BLMice, KnockoutReal-Time Polymerase Chain ReactionRetinal Pigment EpitheliumTomography, Optical CoherenceAnimalsEnzyme-Linked Immunosorbent AssayImmunohistochemistryMacular DegenerationMicePhotoreceptor Cells, VertebrateComplement C3Iodatessodium iodateAMDC3Retinal degenerationRetinal protectionSodium iodate

Identifiers

PMID39557279
PMCPMC11625604

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.