Evidence map›Paper›PMID 39556782›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2025

Autoantibodies Against Dihydrolipoamide S-Acetyltransferase Are Not Associated With Immune-Mediated Neuropathies.

Alexandre Jentzer, Jérémie El-Bechir, Guillaume Taieb, Jérôme J Devaux

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandre JentzerFrom the Department of Immunology (A.J.), CHU Montpellier; Institut de Génomique Fonctionnelle (A.J., J.E.-B., G.T., J.D.), Université de Montpellier, CNRS, INSERM; and Department of Neurology (G.T.), CHU Montpellier, France.ORCID 0000-0002-0223-4359
Jérémie El-BechirFrom the Department of Immunology (A.J.), CHU Montpellier; Institut de Génomique Fonctionnelle (A.J., J.E.-B., G.T., J.D.), Université de Montpellier, CNRS, INSERM; and Department of Neurology (G.T.), CHU Montpellier, France.
Guillaume TaiebFrom the Department of Immunology (A.J.), CHU Montpellier; Institut de Génomique Fonctionnelle (A.J., J.E.-B., G.T., J.D.), Université de Montpellier, CNRS, INSERM; and Department of Neurology (G.T.), CHU Montpellier, France.ORCID 0000-0001-6940-8926
Jérôme J DevauxFrom the Department of Immunology (A.J.), CHU Montpellier; Institut de Génomique Fonctionnelle (A.J., J.E.-B., G.T., J.D.), Université de Montpellier, CNRS, INSERM; and Department of Neurology (G.T.), CHU Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDihydrolipoamide S-acetyltransferase (DLAT), the E2 component of the mitochondrial pyruvate dehydrogenase complex (PDC-E2), has recently been suggested to be a biomarker of chronic inflammatory demyelinating polyneuropathy (CIDP). It was particularly associated with sensory variants of CIDP. Antimitochondrial antibodies are important for the diagnosis of primary biliary cholangitis, but insofar, only 2 studies have reported an association with CIDP. Here, we aimed to validate these observations in a cohort of French patients with immune-mediated neuropathy.

methodsThe positivity against PDC-E2/DLAT was examined using ELISA and confirmed using commercially available immuno-DOT and by indirect immunofluorescence on stomach, kidney, and liver sections.

resultsNone of the 20 healthy controls, 31 patients with Guillain-Barré syndrome, 102 patients with CIDP (including 24 patients with sensory CIDP), 26 patients with monoclonal gammopathy, 23 patients with Charcot-Marie-Tooth disease, or 20 patients with autoimmune nodopathy showed IgG against PDC-E2/DLAT. DISCUSSION: PDC-E2/DLAT is accurately a target antigen in immune-mediated neuropathies.

Indexed as

AutoantibodiesDihydrolipoyllysine-Residue AcetyltransferasePolyradiculoneuropathy, Chronic Inflammatory DemyelinatingAdultAgedAutoantigensCohort StudiesFemaleGuillain-Barre SyndromeHumansMaleMiddle AgedMitochondrial ProteinsAutoantibodiesAutoantigensDihydrolipoyllysine-Residue AcetyltransferaseDLAT protein, humanMitochondrial Proteins

Identifiers

PMID39556782
PMCPMC11727599

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