ArticleAnnals of clinical and translational neurology2025
Dopaminergic therapy disrupts decision-making in impulsive-compulsive Parkinsonian patients.
Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Contributions of the interaction between mu-opioid receptors and dopamine receptors in the regulation of risky decision making.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Positive demography: changing the perspective on population aging from the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB-), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB- nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.
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