ArticleAnnals of clinical and translational neurology2025
Incremental clinical value of intraplaque neovascularization in predicting recurrent ischemic stroke.
Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dynamic Prediction of 3-Month Recurrence After First-Ever Ischemic Stroke Using a Two-Stream Attention-LSTM Model - Henan Province, China, 2025.China CDC weekly · 2026Article
- Associations of Different Inflammatory Markers with Neurological Deficit Severity and Short-Term Prognosis in Young Patients with Ischemic Stroke.Journal of inflammation research · 2026Article
- AngioPLUS-derived carotid intraplaque neovascularization predicts recurrent anterior circulation stroke: a prospective cohort study.Frontiers in neurology · 2026Article
- The lipid ratio castelli's risk index II is a novel biomarker for intraplaque neovascularization in patients with carotid stenosis.Lipids in health and disease · 2025Article
- A correlation study on triglyceride-glucose index and extensive neovascularization within carotid artery plaques.Diabetology & metabolic syndrome · 2025Article
- Predictive value of contrast-enhanced ultrasound in assessing the risk of recurrent in ipsilateral anterior circulation ischemic stroke.BMC medical imaging · 2025Article
- Risk prediction for symptomatic ischemic cerebrovascular disease based on ultrasound indicators of carotid plaque neovascularization.Frontiers in cardiovascular medicine · 2025Article
- The "angiogenesis-plaque stability paradox" in atherosclerosis pathogenesis.Frontiers in cardiovascular medicine · 2025Review
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6 authors.
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Abstract
objectiveCarotid intraplaque neovascularization (IPN) detected by contrast-enhanced ultrasound (CEUS) is a risk factor for recurrent ischemic stroke. However, it is still unclear whether IPN can be used to accurately identify patients with recurrent ischemic stroke in clinical practice. Herein, we investigated the clinical predictive value of IPN for recurrent ischemic stroke in a real-world setting.
methodsWe enrolled 200 patients with ischemic stroke and atherosclerotic carotid stenosis who were followed up for 2 years. The endpoint was recurrent ischemic stroke. Cox regression and subgroup analyses were employed to assess whether treatment affected the relationship between IPN and recurrent ischemic stroke. The net classification index (NRI) and integrated discriminant improvement index (IDI) were used to validate the additional clinical value of IPN in identifying recurrent ischemic stroke.
resultsDuring the 2-year follow-up, 36 patients experienced recurrent ischemic stroke. Cox regression analyses showed that IPN (grade 2), hypoechoic plaque, high homocysteine levels, and smoking were independent risk factors for recurrent ischemic stroke. Additional IPN evaluation may increase the NRI (0.512; 95% confidence interval [CI]: 0.083-0.624) and IDI (0.151; 95% CI: 0.010-0.213) for identifying high-risk patients with recurrent ischemic stroke. In addition, in the subgroup undergoing revascularization, the proportion of IPN (grade 2) was significantly higher in patients with recurrent ischemic stroke than in patients with nonrecurrent ischemic stroke (p = 0.001).
interpretationIn clinical settings, IPN, assessed by CEUS, may provide additional clinical value for predicting recurrent ischemic stroke, helping to identify patients with ischemic stroke who require close follow-up.
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