ArticleeLife2024
Brain state and cortical layer-specific mechanisms underlying perception at threshold.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Nested spatiotemporal theta-gamma waves organize hierarchical processing across the mouse visual cortex.Nature communications · 2026Article
- State-Dependent Dissociation of Shared Input and Directed Information Flow in the Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- The Impact of Artificial and Natural Additives in Meat Products on Neurocognitive Food Perception: A Narrative Review.Foods (Basel, Switzerland) · 2024Review
- Article
- Tonal Tinnitus Does Not Interfere with Tone Detection at the Tinnitus Pitch-Matched Frequency.Trends in hearingArticle
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Authors and funding
6 authors.
Funding
Abstract
Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in behavioral state and cortical layer and cell class-specific neural activity underlie this perceptual variability. We analyzed physiological measurements of state and laminar electrophysiological activity in visual area V4 while monkeys were rewarded for correctly reporting a stimulus change at perceptual threshold. Hit trials were characterized by a behavioral state with heightened arousal, greater eye position stability, and enhanced decoding performance of stimulus identity from neural activity. Target stimuli evoked stronger responses in V4 in hit trials, and excitatory neurons in the superficial layers, the primary feed-forward output of the cortical column, exhibited lower variability. Feed-forward interlaminar population correlations were stronger on hits. Hit trials were further characterized by greater synchrony between the output layers of the cortex during spontaneous activity, while the stimulus-evoked period showed elevated synchrony in the feed-forward pathway. Taken together, these results suggest that a state of elevated arousal and stable retinal images allow enhanced processing of sensory stimuli, which contributes to hits at perceptual threshold.
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Registered trials
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