Evidence map›Paper›PMID 39556302›Full record

ArticleWiener medizinische Wochenschrift (1946)2025

Value of mean platelet volume for diagnosing esophagitis in children with gastroesophageal reflux disease.

Azin Gouran, Mohammadreza Esmaeili Dooki, Hossein-Ali Nikbakht, Hassan Mahmoodi, Mohammad Pornasrolah, Maryam Nikpour, Sanaz Mehrabani

Abstract read
PubMed Publisher
In one paragraph

Article in Wiener medizinische Wochenschrift (1946), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Azin GouranStudent Research Committee, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Mohammadreza Esmaeili DookiNon-communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Hossein-Ali NikbakhtNon-communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Hassan MahmoodiNon-communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Mohammad PornasrolahThe Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran.
Maryam NikpourNon-communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Sanaz MehrabaniNon-communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. mehrabanisanaz@gmail.com.ORCID http://orcid.org/0000-0002-0890-1298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of gastroesophageal reflux disease (GERD) in children is increasing in different societies. This study aims to investigate the value of mean platelet volume (MPV) for diagnosing esophagitis in children with GERD.

methodsThis cross-sectional study conducted at Amirkola Children's Hospital between 2022 and 2023 involved children aged 2 to 16 years diagnosed with GERD. The diagnosis was based on the GSQ-YC and GASP‑Q questionnaires. All patients underwent endoscopy, with a biopsy for pathology and a blood sample for MPV analysis. The data were then analyzed using SPSS software version 22 (IBM Corp., Armonk, NY, USA), with a significance level set at lower than 0.05.

resultsThe frequency of esophagitis among 194 participants was 39.7%. The overall sensitivity and specificity of MPV for diagnosing esophagitis in children were 64.63% and 52.14%, respectively (area under the curve [AUC] = 0.59). In terms of gender, the overall sensitivity and specificity of the MPV were 85.00% and 32.65% in boys and 70.27% and 51.47% in girls (AUC = 0.58 and AUC = 0.61, respectively). In terms of age, the overall sensitivity and specificity of MPV in children under 12 years were 52.46% and 62.26% and in children older than 12 years 87.5% and 36.36% (AUC = 0.58 and AUC = 0.55, respectively).

conclusionIn summary, the results of this study indicate that MPV is not a reliable method for diagnosing esophagitis in children with GERD.

Indexed as

EsophagitisGastroesophageal RefluxMean Platelet VolumeAdolescentChildChild, PreschoolCross-Sectional StudiesFemaleHumansMaleSensitivity and SpecificityChildrenEsophagitisGastroesophageal refluxMean platelet volume

Identifiers

PMID39556302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.