ArticleClinical rheumatology2025
Brain computed tomography perfusion alterations in patients with Takayasu arteritis with steno-occlusive carotid arteries: a retrospective study.
Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Cognitive outcomes after extracranial-intracranial bypass surgery in elderly patients diagnosed with atherosclerotic cerebral steno-occlusive artery disease.Frontiers in aging neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
INTRODUCTION/
objectiveData on computed tomography perfusion (CTP) in Takayasu arteritis (TAK) patients are limited. Herein, we used CTP combined with computed tomography angiography (CTA) to investigate the brain hemodynamic status in TAK patients with stenosis/occlusive carotid arteries.
methodsWe retrospectively analyzed 49 TAK patients with carotid artery stenosis or occlusion who had ischemic manifestations and completed a one-stop aortic CTA and brain CTP at Xijing Hospital between 2021 and 2023. Hemodynamic parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to maximum (Tmax), were compared between groups using independent samples t-test or the Mann-Whitney U test. Relationships among CTP parameters and disease activity were evaluated by correlation analyses.
resultsAmong 49 patients (43 females; age 38.7 ± 11.1 years), 15 had common carotid artery occlusion (four bilateral, six right, and five left). Compared with the non-occlusion group, the occlusion group had longer MTT and Tmax (p < 0.05) but showed no differences in CBV and CBF values. Patients with different degrees of lesions on two sides of the carotid artery (n = 31) had lower mean CBF on the severely affected side than on the contralateral side (p = 0.022). In contrast, mean MTT (p = 0.036) and Tmax (p = 0.024) were longer. Patients with more severe ischemic symptoms had longer Tmax than patients with mild symptoms (p < 0.05). Tmax was moderately correlated with disease activity indices (p < 0.05).
conclusionsAlterations in cerebral hemodynamic perfusion were observed in TAK patients. The implications of these findings in evaluating brain ischemia and dysfunction require further investigation. Key Points • Alterations in cerebral hemodynamic perfusion were observed in TAK patients. • Compared with patients without common carotid artery occlusion, patients with occlusion had longer MTT and Tmax values. • In patients with different degrees of lesions on the two sides of the carotid artery, the severely affected side had a lower CBF and prolonged MTT and Tmax than the contralateral side. • Patients with moderate-to-severe ischemic manifestations had a longer Tmax than patients with mild symptoms, and MTT and Tmax correlated with disease activity indices.
Indexed as
Identifiers
39556144What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.