Evidence map›Paper›PMID 39556051›Full record

ArticleJournal of anatomy2025

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis).

Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A Young

Abstract read
In one paragraph

Article in Journal of anatomy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hadyn DeLeeuwDepartment of Anatomy, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, USA.
Michael CrambergDepartment of Anatomy, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, USA.
Matthew DilleDepartment of Anatomy, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, USA.
Emily PickDepartment of Anatomy, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, USA.
Mary ThompsonDepartment of Anatomy, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, USA.
Bruce A YoungDepartment of Anatomy, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, USA.ORCID 0000-0002-0988-7731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of anatomical techniques, imaging modalities, dyes and contrast agents, were used to document the mechanisms/routes whereby spinal cerebrospinal fluid (CSF) would move beyond the confines of the spinal dura in the American alligator, Alligator mississippiensis. Three pathways for CSF loss were identified: spinal arachnoid granulations, perineural flow along the spinal nerves, and lymphatic drainage (both along the surface of the dura and at the venous plexus surrounding the spinal ganglion). These same three pathways for spinal CSF loss have been documented in mammals, suggesting that they may be a common feature of (at least) amniotes. Crocodilians, including A. mississippiensis, have the largest epidural venous sinus system of any vertebrate, the present study suggests that, as in mammals, the venous complex of the alligator plays a direct role in regulating the absorption of CSF from the spinal compartment.

Indexed as

Alligators and CrocodilesCerebrospinal FluidSpinal CordAnimalsDura Materarachnoid granulationsink cufflymphaticperineuralsubarachnoid angle

Identifiers

PMID39556051
PMCPMC11911136

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.