Evidence map›Paper›PMID 39555918›Full record

ReviewmBio2024

Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host-immune interactions in human fungal pathogens.

Philipp Brandt, Rima Singha, Iuliana V Ene

Abstract readReview
In one paragraph

Review in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Extracellular vesicles ofInfection and immunity · 2026
    Article
  7. Caspofungin Reshapes the Extracellular Vesicles Metabolome ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  8. Extracellular vesicles produced byExtracellular vesicles and circulating nucleic acids · 2026
    Review
  9. Selective DNA encapsulation in extracellular vesicles ofExtracellular vesicles and circulating nucleic acids · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Host cell responses toFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Philipp Brandt *Institut Pasteur, Université Paris Cité, Fungal Heterogeneity Group, Paris, France.
Rima Singha *Institut Pasteur, Université Paris Cité, Fungal Heterogeneity Group, Paris, France.
Iuliana V EneInstitut Pasteur, Université Paris Cité, Fungal Heterogeneity Group, Paris, France.ORCID 0000-0002-0390-7084

Funding

Agence Nationale de la Recherche (ANR) RESISTEVCIFARInstitut Pasteur PTR MECHETE
6 · The paper itself

Abstract

Pathogenic fungi pose a significant threat to human health, especially given the rising incidence of invasive fungal infections and the emergence of drug-resistant strains. This requires the development of vaccines and the advancement of antifungal strategies. Recent studies have focused on the roles of fungal extracellular vesicles (EVs) in intercellular communication and host-pathogen interactions. EVs are nanosized, lipid membrane-bound particles that facilitate the transfer of proteins, lipids, and nucleic acids. Here, we review the multifaceted functions of EVs produced by different human fungal pathogens, highlighting their importance in the response of fungal cells to different environmental cues and their interactions with host immune cells. We summarize the current state of research on EVs and how leveraging this knowledge can lead to innovative approaches in vaccine development and antifungal treatment.

Indexed as

BiofilmsExtracellular VesiclesFungiHost-Pathogen InteractionsAdaptation, PhysiologicalHumansMycosesStress, Physiologicalbiofilmsdrug resistanceextracellular vesiclesfungal pathogensimmunitystress response

Identifiers

PMID39555918
PMCPMC11633191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.