Evidence map›Paper›PMID 39555916›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.

Allison C Engstrom, John Paul M Alitin, Arunima Kapoor, Shubir Dutt, Trevor Lohman, Isabel J Sible, Anisa J Marshall, Fatemah Shenasa, Aimée Gaubert, Farrah Ferrer and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Allison C EngstromDepartment of Psychological Science, University of California, Irvine, Irvine, California, USA.
John Paul M AlitinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, California, USA.
Shubir DuttMemory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Trevor LohmanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Anisa J MarshallDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Fatemah ShenasaDepartment of Psychological Science, University of California, Irvine, Irvine, California, USA.
Aimée GaubertLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Farrah FerrerLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Amy NguyenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
David Robert BradfordCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Kathleen RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Lorena SordoDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
Xingfeng ShaoStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA.
Danny J J WangStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-9123-0658

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
CIHR DFD-170763NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073NIH HHS P01AG052350NIH HHS P30AG066530NIH HHS R01AG060049NIH HHS R01AG064228NIH HHS R01AG082073
6 · The paper itself

Abstract

introductionOlder adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory impairment.

methodsOne hundred sixty-one older adults free of dementia or major neurological/psychiatric disorders were recruited. Participants underwent clinical interviews, cognitive testing, venipuncture for Alzheimer's disease (AD) biomarkers, and brain magnetic resonance imaging. Spontaneous CVR was quantified during 5 minutes of rest. Respiratory gases analyzed through nasal cannula to quantify end-tidal carbon dioxide (

resultsWhole brain CVR was negatively associated with age, but not MCI. Lower CVR in the parahippocampal gyrus (PHG) was found in participants with MCI and was linked to worse memory performance on memory tests. Results remained significant after adjusting for AD biomarkers and vascular risk factors. DISCUSSION: Spontaneous CVR deficits in the PHG are observed in older adults with MCI and memory impairment, suggesting medial temporal microvascular dysfunction is observed in cognitive decline. HIGHLIGHTS: Aging is associated with decline in whole brain spontaneous cerebrovascular reactivity (CVR). Older adults with mild cognitive impairment exhibit deficits in spontaneous CVR in the parahippocampal gyrus (PHG). Memory impairment is correlated with reduced spontaneous CVR in the PHG.

Indexed as

BrainCerebrovascular CirculationCognitive DysfunctionMemory DisordersRestAgedAged, 80 and overApolipoproteins EBiomarkersFemaleGenotypeGeriatric AssessmentHeart Disease Risk FactorsHumansMagnetic Resonance ImagingMaleApolipoproteins EBiomarkersamnestic mild cognitive impairmentmemory impairmentmild cognitive impairmentspontaneous cerebrovascular reactivity

Identifiers

PMID39555916
PMCPMC11772704

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.