Evidence map›Paper›PMID 39555865›Full record

ReviewJPEN. Journal of parenteral and enteral nutrition2025

What do we know about micronutrients in critically ill patients? A narrative review.

Angelique M E de Man, Christian Stoppe, Kristine W A C Koekkoek, George Briassoulis, Lilanthi S D P Subasinghe, Cristian Cobilinschi, Adam M Deane, William Manzanares, Ioana Grințescu, Liliana Mirea and 18 more

Abstract readReview
In one paragraph

Review in JPEN. Journal of parenteral and enteral nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Trial
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  4. Review
  5. Article
  6. Review
  7. What do we know about micronutrients in critically ill patients? A narrative review.JPEN. Journal of parenteral and enteral nutrition · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Angelique M E de ManDepartment of Intensive Care; Amsterdam Cardiovascular Sciences, Amsterdam UMC, location Vrije Universiteit, Amsterdam, the Netherlands.
Christian StoppeUniversity Hospital Wuerzburg, Department of Anaesthesiology, Intensive Care, Emergency, and Pain Medicine, Wuerzburg, Germany.
Kristine W A C KoekkoekDepartment of Intensive Care Medicine, Martini Hospital, Groningen, The Netherlands.
George BriassoulisPostgraduate Program, Emergency and Intensive Care in Children Adolescents and Young Adults, School of Medicine, University of Crete, Heraklion, Greece.ORCID 0000-0003-0928-6183
Lilanthi S D P SubasingheHead of the Department - Division of Intensive Care, University Hospital, General Sir John Kotelawala Defence University, Colombo, Sri Lanka.
Cristian CobilinschiDepartment of Anesthesiology and Intensive Care II, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.ORCID 0000-0002-1142-7427
Adam M DeaneDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Parkville, Vic, Australia.
William ManzanaresDepartment of Critical Care, Hospital de Clínicas (University Hospital), Faculty of Medicine, UdelaR, Montevideo, Uruguay.ORCID 0000-0002-6060-0329
Ioana GrințescuDepartment of Anesthesiology and Intensive Care II, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Liliana MireaDepartment of Anesthesiology and Intensive Care II, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Ashraf RoshdyCritical Care Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Antonella CotoiaDepartment of Critical Care, University Hospital of Foggia, Foggia, Italy.
Danielle E BearDepartment of Nutritional Sciences, School of Life Course and Population Sciences, King's College London, London, UK.
Sabrina BorasoGeneral and Neurosurgical Intensive Care Unit, Ospedale dell'Angelo, Mestre-Venezia, Italy.
Vincent FraipontIntensive Care Unit, Hôpital de la Citadelle, Liège, Belgium.
Kenneth B ChristopherChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, USA.
Michael P CasaerDepartment of Cellular and Molecular Medicine, Laboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7087-0795
Jan GunstDepartment of Cellular and Molecular Medicine, Laboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium.
Olivier PantetDepartment of Intensive Care Medicine, University Hospital of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6195-8947
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Giuliano BolondiAnesthesia and Intensive Care Unit, Ospedale Bufalini, Cesena (FC), Italy.
Xavier ForcevilleInserm, CIC 1414 (Centre d' Investigation Clinique de Rennes), Univ Rennes, CHU Rennes, Rennes, F-35000, France.
Matthias W A AngstwurmDepartment of Medicine IV, LMU University Hospital, LMU Munich, Germany.
Mohan GurjarDepartment of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India.
Rodrigo BiondiHead of ICU, Hospital Brasília Lago Sul, Brazil.ORCID 0000-0002-9242-6062
Arthur R H van ZantenDepartment of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, the Netherlands; Wageningen University & Research, Division of Human Nutrition and Health, Wageningen, the Netherlands.
Mette M BergerFaculty of Biology and Medicine, Lausanne University, Lausanne, Switzerland.
ESICM/FREM MN group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micronutrient (MN) status alterations (both depletion and deficiency) are associated with several complications and worse outcomes in critically ill patients. On the other side of the spectrum, improving MN status has been shown to be a potential co-adjuvant therapy. This review aims to collect existing data to better guide research in the critical care setting. This narrative review was conducted by the European Society of Intensive Care Medicine Feeding, Rehabilitation, Endocrinology, and Metabolism MN group. The primary objective was to identify studies focusing on individual MNs in critically ill patients, selecting the MNs that appear to be most relevant and most frequently investigated in the last decade: A, B

Indexed as

Critical IllnessMicronutrientsCritical CareHumansNutritional RequirementsNutritional StatusSeleniumMicronutrientsSeleniumcritical illnessinflammationmicronutrientsnutritionoxidative stress

Identifiers

PMID39555865
PMCPMC11717498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.