Evidence map›Paper›PMID 39555495›Full record

ArticleEpilepsy & behavior reports2024

Exercise, memory, and the hippocampus: Uncovering modifiable lifestyle reserve factors in refractory epilepsy.

Alena Stasenko, Erik Kaestner, Adam Schadler, Evan Brady, Jonathan Rodriguez, Rebecca W Roth, Ezequiel Gleichgerrcht, Jonathan L Helm, Daniel L Drane, Carrie R McDonald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alena StasenkoDepartment of Psychiatry, University of California, San Diego, USA.
Erik KaestnerDepartment of Radiation Medicine & Applied Sciences, University of California, San Diego, USA.
Adam SchadlerDepartment of Radiation Medicine & Applied Sciences, University of California, San Diego, USA.
Evan BradyDepartment of Neurology, Emory University, USA.
Jonathan RodriguezDepartment of Neurosciences, University of California, San Diego, USA.
Rebecca W RothDepartment of Neurology, Emory University, USA.
Ezequiel GleichgerrchtDepartment of Neurology, Emory University, USA.
Jonathan L HelmDepartment of Psychology, San Diego State University, USA.
Daniel L DraneDepartment of Neurology, Emory University, USA.
Carrie R McDonaldDepartment of Psychiatry, University of California, San Diego, USA.

Funding

BRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigationof vascular, genetic, and biomarker risk profiles in elderly patients with epilepsyR01NS120976 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$4.1M
Lifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8M
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-makingR01NS124585 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2022 to 2025
$3.3M
NINDS NIH HHS R01 NS120976NINDS NIH HHS R01 NS122827NINDS NIH HHS R01 NS124585
6 · The paper itself

Abstract

Physical exercise is an emerging target for improving cognition in aging and neurological disease. Due to the beneficial impact of exercise on hippocampal health and the vulnerability of the hippocampus in medication-resistant temporal lobe epilepsy (TLE), exercise could present a promising intervention in TLE. We investigated whether exercise engagement is associated with verbal memory function and hippocampal integrity in 29 young to middle-aged adults with refractory TLE and 21 demographically matched controls. Participants completed a self-reported questionnaire of weekly exercise, three tests of verbal memory, and a subset (

Indexed as

CognitionCognitive reserveEpilepsyExerciseHippocampusMemoryPhysical activityResilience

Identifiers

PMID39555495
PMCPMC11567920

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.