Evidence map›Paper›PMID 39555363›Full record

ArticleIndian journal of surgical oncology2024

A Short Course of Preoperative Denosumab Injection Followed by Surgery in High-Risk Giant Cell Tumors of the Extremities: A Retrospective Study.

Sujit Kumar Tripathy, Saroj Das Majumdar, Siddharth Satyakam Pradhan, Paulson Varghese, Hrudeswar Behera, Anand Srinivasan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sujit Kumar TripathyDept. of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019 India.ORCID 0000-0003-0179-9910
Saroj Das MajumdarDepartment of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India.
Siddharth Satyakam PradhanDept. of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019 India.
Paulson VargheseDept. of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019 India.
Hrudeswar BeheraDept. of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019 India.
Anand SrinivasanDepartment of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite early promising results with denosumab treatment in giant cell tumor of bone (GCTB), recent studies have raised concerns about a high local recurrence rate following preoperative denosumab administration and joint preservation surgery. This retrospective study evaluated data from 25 high-risk GCT patients (Campanacci grade II or III with features like soft tissue extension, pathological fracture, minimal periarticular or subarticular bone) treated with five doses of neoadjuvant denosumab injection followed by either curettage and cementing (

Indexed as

BisphosphonateKnee jointLong boneOsteoclastomaRANK ligandTumor

Identifiers

PMID39555363
PMCPMC11564612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.