Evidence map›Paper›PMID 39555327›Full record

ArticleAphasiology2024

Cerebellar tDCS Enhances Functional Communication Skills in Chronic Aphasia.

Ji Hyun Kim, Sarah Cust, Becky Lammers, Shannon M Sheppard, Lynsey M Keator, Donna C Tippett, Argye E Hillis, Rajani Sebastian

Abstract read
In one paragraph

Article in Aphasiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ji Hyun KimDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-0927-3764
Sarah CustDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.
Becky LammersDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.
Shannon M SheppardDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-4053-8617
Lynsey M KeatorDepartment of Linguistics and Cognitive Science, University of Delaware, Newark, DE.ORCID 0000-0002-9064-6950
Donna C TippettDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.
Argye E HillisDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-5192-1171
Rajani SebastianDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RORDEN, CHRISTOPHER · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Cerebellar stimulation for Aphasia RehabilitationR01DC019639 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Rajani Sebastian · 2022 to 2026
$3.5M
Cerebellar Transcranial Direct Current Stimulation to Augment Chronic Aphasia TreatmentR00DC015554 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI SEBASTIAN, RAJANI · 2018 to 2020
$720k
Cerebellar stimulation for Aphasia RehabilitationR56DC019639 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI SEBASTIAN, RAJANI · 2021 to 2021
$663k
Cerebellar Transcranial Direct Current Stimulation to Augment Chronic Aphasia TreatmentK99DC015554 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI SEBASTIAN, RAJANI · 2016 to 2017
$176k
NIDCD NIH HHS K99 DC015554NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R00 DC015554NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC019639NIDCD NIH HHS R56 DC019639
6 · The paper itself

Abstract

Background: Transcranial direct current stimulation (tDCS) has emerged as a possible neuromodulatory tool to augment language therapy in post-stroke aphasia. However, there is limited information on whether tDCS may help to improve everyday functional communication. Aims: To investigate whether cerebellar tDCS combined with computerized aphasia treatment improves functional communication skills in individuals with chronic aphasia. Methods and Procedures: In a randomized, double-blind, sham-controlled, within-subject crossover study, participants received 15 sessions of anodal (n=14) or cathodal (n=14) cerebellar tDCS plus computerized aphasia treatment then sham plus computerized aphasia treatment, or the opposite order. Linear mixed-effects regression models were performed to evaluate (1) the effect of tDCS treatment on change in functional communication skills on the two dimensions of the American Speech-Language-Hearing Association Functional Assessment of Communication Skills for Adults (ASHA-FACS): Communication Independence (CI) scale and Qualitative Dimension of Communication (QDC) scale, and (2) the relationship between functional communication skills and trained and untrained naming abilities. Outcomes and Results: The results showed significant tDCS-induced gains for the overall QDC mean score, but not for the overall CI mean score. Cerebellar stimulation was more effective than sham for the overall QDC mean score immediately post-treatment, 2-weeks post-treatment and 2-months post-treatment. Follow up analysis separated by group showed that the change in the overall QDC mean score (combining both phases) were similar in participants receiving anodal or cathodal stimulation. We also found a significant linear association between ASHA-FACS overall CI mean change scores and trained and untrained naming change scores for the tDCS condition but not sham. Conclusions: Our study provides preliminary evidence that cerebellar tDCS coupled with computerized aphasia treatment has the potential to improve the overall qualitative dimensions of functional communication skills in individuals with chronic aphasia.

Indexed as

AphasiaCerebellar tDCSFunctional CommunicationLanguage TherapyStroke

Identifiers

PMID39555327
PMCPMC11566018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.