ArticleNature catalysis2024
Split cross-coupling via Rh-catalysed activation of unstrained aryl-aryl bonds.
Article in Nature catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Catalytic C-Demethylation of Phenols and Anilines Enabled by a Removable Mono-Directing Group.Journal of the American Chemical Society · 2026Article
- "Cut-and-Sew" Reactions of β-Lactams via C-C Bond Activation.Journal of the American Chemical Society · 2025Article
- Site-selective Ru-catalysed saturation of unactivated arenes via directed 6π activation.Nature catalysis · 2025Article
- Ring Expansion via Palladium-Catalyzed Aryne Insertion into C-C Bonds of Benzocyclobutenones.Angewandte Chemie (International ed. in English) · 2025Article
- Skeletal Modification via Activation of Relatively Unstrained C-C Bonds.Accounts of chemical research · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Constructive functionalization of unstrained aryl-aryl bonds has been a fundamental challenge in organic synthesis due to the inertness of these bonds. Here we report a split cross-coupling strategy that allows two-fold arylation with diverse aryl iodides through cleaving unstrained aryl-aryl bonds of common 2,2'-biphenols. The reaction is catalyzed by a rhodium complex and promoted by a removable phosphinite directing group and an organic reductant. The combined experimental and computational mechanistic studies reveal a turnover-limiting reductive elimination step that can be accelerated by a Lewis acid co-catalyst. The utility of this coupling method has been illustrated in the modular and simplified syntheses of unsymmetrical 2,6-diarylated phenols and skeletal insertion of phenyl units.
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Registered trials
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