Evidence map›Paper›PMID 39554799›Full record

ArticleJournal of oncology research and therapy2019

Pro-Inflammatory Milieu in Human Kidney Perfusates Treated with Hypothermic Pulsatile Machine Perfusion.

Emmett Ratigan, Sashi Kasimsetty, Jeffrey Cohen, Alana Shigeoka, Lisa Stocks, Kristin Mekeel, Robert Steiner, Dianne B McKay

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of oncology research and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emmett RatiganDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Sashi KasimsettyDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.
Jeffrey CohenDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Alana ShigeokaScripps Clinic and Green Hospital, La Jolla, CA, USA.
Lisa StocksDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Kristin MekeelDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Robert SteinerDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Dianne B McKayDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.

Funding

HYPERTENTIONT32HL007261 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMSON, SCOTT CULVER · 1985 to 2015
$4.9M
Role of Nlrp3 in Ischemic Organ InjuryR01DK091136 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCKAY, DIANNE B · 2011 to 2015
$1.8M
Role of NOD2 in ischemia reperfusion injuryR01DK113162 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCKAY, DIANNE B · 2017 to 2020
$1.6M
NHLBI NIH HHS T32 HL007261NIDDK NIH HHS R01 DK091136NIDDK NIH HHS R01 DK113162
6 · The paper itself

Abstract

Hypothermic Machine Perfusion (HMP) has been shown to decrease Delayed Graft Function (DGF) and improve outcomes of deceased donor kidney transplants. Although the mechanisms of protection afforded by HMP have not yet been defined, this study tested the hypothesis that HMP improves transplant outcomes by clearing pro-inflammatory molecules from the allograft during pumping. Here we report on 26 allografts preserved via pulsatile HMP at our organ procurement organization that were prospectively evaluated for the time-dependent clearance of cytokines, chemokines and injury markers during their time on pump. Of the cytokines and chemokines measured, IL-1RA, IL-6, IL-18, INFγ, and MCP-1 were increased in the pump perfusate over time and were correlated with markers of kidney injury. Over time on pump, the 'Danger' molecule HMGB1 appeared in the perfusate, and perfusate samples activated T-cells

Indexed as

HMGB1Hypothermic Machine PerfusionInflammationKidney TransplantPro-inflammatory MoleculesRenal Tubular Epithelial CellsT cells

Identifiers

PMID39554799
PMCPMC11566414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.