Evidence map›Paper›PMID 39554788›Full record

ArticleNeuro-oncology practice2024

Validation of the graded prognostic assessment and recursive partitioning analysis as prognostic tools using a modern cohort of patients with brain metastases.

Jacob Sperber, Seeley Yoo, Edwin Owolo, Tara Dalton, Tanner J Zachem, Eli Johnson, James E Herndon, Annee D Nguyen, Harrison Hockenberry, Brandon Bishop and 7 more

Abstract read
In one paragraph

Article in Neuro-oncology practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jacob SperberDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-6290-7300
Seeley YooDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
Edwin OwoloDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
Tara DaltonDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0003-4796-6948
Tanner J ZachemDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-3129-1133
Eli JohnsonDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
James E HerndonDepartment of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Annee D NguyenDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
Harrison HockenberryDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
Brandon BishopDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
Nancy Abu-BonsrahDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Steven H CookDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
Peter E FecciDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-2912-8695
Paul W SperdutoDuke Radiation Oncology, Duke University School of Medicine, Durham, North Carolina, USA.
Margaret O JohnsonDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
Melissa M EricksonDepartment of Orthopaedics, Duke University School of Medicine, Durham, North Carolina, USA.
C Rory GoodwinDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-6540-2751

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prognostic indices for patients with brain metastases (BM) are needed to individualize treatment and stratify clinical trials. Two frequently used tools to estimate survival in patients with BM are the recursive partitioning analysis (RPA) and the diagnosis-specific graded prognostic assessment (DS-GPA). Given recent advances in therapies and improved survival for patients with BM, this study aims to validate and analyze these 2 models in a modern cohort. Methods: Patients diagnosed with BM were identified via our institution's Tumor Board meetings. Data were retrospectively collected from the date of diagnosis with BM. The concordance of the RPA and GPA was calculated using Harrell's Results: Our study consisted of 206 patients diagnosed with BM between 2010 and 2019. The RPA had a prediction performance characterized by Harrell's Conclusions: We found that the performance of the RPA remains unchanged from previous validation studies a decade earlier. The DS-GPA outperformed the RPA in predicting overall survival in our modern cohort. Analyzing variables shared by the RPA and DS-GPA produced a model that performed analogously to the DS-GPA.

Indexed as

brain metastasesGPApredictive modelsprognostic factorsRPA

Identifiers

PMID39554788
PMCPMC11567744

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.