ArticleNeurophotonics2024
Cerebral baseline optical and hemodynamic properties in pediatric population: a large cohort time-domain near-infrared spectroscopy study.
Article in Neurophotonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- "hDOS": an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision andJournal of biomedical optics · 2025Article
- Investigating brain haemodynamics during hypoglycaemia in very preterm neonates using diffuse optical tomography.medRxiv : the preprint server for health sciences · 2025Article
- Two-layer dynamic blood phantom for assessing NIRS device accuracy.Biomedical optics express · 2025Article
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10 authors.
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Abstract
Significance: Reference cerebral near-infrared spectroscopy (NIRS) data on the pediatric population are scarce, and in most cases, only cerebral oxygen saturation ( Aim: We aimed at collecting baseline cerebral optical parameters [absorption coefficient, Approach: TD NIRS measurements were performed in the prefrontal cortex at 686 and 830 nm with a 2.5-cm source-detector distance and 1-Hz acquisition rate. Five independent measurements (after probe replacement) were taken for every subject. TD NIRS data were fitted to a photon diffusion model to estimate the optical parameters. From the absorption coefficients, the hemodynamic parameters were derived by Beer's law. Auxological and physiological information was also collected to explore the potential correlations with NIRS data. Results: We measured 305 patients in the age range of 2 to 18 years. Absolute values for baseline optical and hemodynamic parameters were shown as a function of age and auxological variables. From the analysis of the repositioning after probe replacement, the time-domain near-infrared spectroscopy device exhibited an average precision (intended as coefficient of variation) of Conclusions: We provided baseline values for optical and hemodynamic parameters in a large cohort of healthy pediatric subjects with good precision, providing a foundation for future investigations into clinically relevant deviations in these parameters.
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