Evidence map›Paper›PMID 39554565›Full record

ArticleJournal of gastrointestinal oncology2024

A predictive model based on radiomics, clinical features, and pathologic indicators for disease-free survival after liver transplantation for hepatocellular carcinoma: a 7-year retrospective study.

Hao Xie, Bin Shi, Junzhen Fan, Shui Liu, Qiaozhi Ma, Junnan Dai, Siqing Dong, Ying Liu, Han Meng, Hui Liu and 2 more

Abstract read
In one paragraph

Article in Journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Hao XiePostgraduate Training Base of the Third Medical Center of Chinese PLA General Hospital, Jinzhou Medical University, Beijing, China.
Bin ShiDepartment of Organ Transplantation, the Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Junzhen FanDepartment of Pathology, the Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Shui LiuDepartment of Radiology, Aerospace Center Hospital, Beijing, China.
Qiaozhi MaDepartment of Radiology, the Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Junnan DaiDepartment of Radiology, the Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Siqing DongDepartment of Radiation Oncology, Jinzhou Central Hospital, Jinzhou, China.
Ying LiuSchool of Medical Imaging, Weifang Medical University, Weifang, China.
Han MengPostgraduate Training Base of the Third Medical Center of Chinese PLA General Hospital, Jinzhou Medical University, Beijing, China.
Hui LiuDepartment of Radiology, the Jintang First People's Hospital, Chengdu, China.
Ya YangDepartment of Ultrasound Medicine, the Jintang First People's Hospital, Chengdu, China.
Xuetao MuDepartment of Radiology, the Third Medical Center of Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Disease-free survival (DFS) is an essential indicator for evaluating the prognosis of liver transplantation (LT) in hepatocellular carcinoma (HCC) patients. Despite progress in the prediction of DFS by radiomics, only preoperative clinical features have been combined in most studies. The aim of this study was to construct a nomogram model (NM) using preoperative clinical features, radiomics, and postoperative pathological indicators for more effective prediction of DFS. Methods: This was a retrospective study of a single-center cohort comprising 139 HCC patients. Using the whole cohort, we constructed and assessed a clinical model (CM) based on alpha-fetoprotein (AFP) and alkaline phosphatase (ALP), a pathological model (PM) based on Ki-67 and tumor number, a radiomics model (RM) based on the radiomics score (Rad-score), and an NM based on the above five independent predictors. Results: Significant correlations between the NM and DFS were observed in the training and validation cohorts. Among the four prediction models, the C-index of the NM was the highest [(training/validation cohort) CM: 0.664/0.676, PM: 0.737/0.691, RM: 0.706/0.697, NM: 0.817/0.760], and the areas under the receiver operating characteristic curves (AUCs) of the NM prediction of 1-year, 2-year, and 3-year DFS were also the highest [(training/validation cohort) 1-year, 2-year, and 3-year CM: 0.726/0.726, 0.685/0.744, 0.645/0.686, PM: 0.789/0.780, 0.801/0.748, 0.841/0.735, RM: 0.769/0.752, 0.717/0.805, 0.748/0.765, NM: 0.882/0.854, 0.867/0.849, 0.882/0.801]. The NM also exhibited the highest net clinical benefit. Conclusions: Based on radiomics, clinical features, and pathological indicators, the NM could be used to effectively predict DFS after LT in HCC patients, guiding the follow-up and complementary treatment.

Indexed as

disease-free survival (DFS)Hepatocellular carcinoma (HCC)liver transplantation (LT)nomogram model (NM)radiomics

Identifiers

PMID39554565
PMCPMC11565123

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