Evidence map›Paper›PMID 39554414›Full record

ArticleACS omega2024

Democratizing Access to Microfluidics: Rapid Prototyping of Open Microchannels with Low-Cost LCD 3D Printers.

Kelsey M Leong, Aileen Y Sun, Mindy L Quach, Carrie H Lin, Cosette A Craig, Felix Guo, Timothy R Robinson, Megan M Chang, Ayokunle O Olanrewaju

Abstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelsey M LeongDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.ORCID https://orcid.org/0009-0004-4258-9009
Aileen Y SunDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.
Mindy L QuachDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, United States.
Carrie H LinDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, United States.
Cosette A CraigDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, United States.
Felix GuoDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, United States.
Timothy R RobinsonDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, United States.
Megan M ChangDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.
Ayokunle O OlanrewajuDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.ORCID https://orcid.org/0000-0003-4776-1774

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microfluidics offer user-friendly liquid handling for a range of biochemical applications. 3D printing microfluidics is rapid and cost-effective compared to conventional cleanroom fabrication. Typically, microfluidics are 3D printed using digital light projection (DLP) stereolithography (SLA), but many models in use are expensive (≥$10,000 USD), limiting widespread use. Recent liquid crystal display (LCD) technology advancements have provided inexpensive (<$500 USD) SLA 3D printers with sufficient pixel resolution for microfluidic applications. However, there are only a few demonstrations of microfluidic fabrication, limited validation of print fidelity, and no direct comparisons between LCD and DLP printers. We compared a 40 μm pixel DLP printer (∼$18,000 USD) with a 34.4 μm pixel LCD printer (<$380 USD). Consistent with prior work, we observed linear trends between designed and measured channel widths ≥4 pixels on both printers, so we calculated accuracy above this size threshold. Using a standard IPA-wash resin and optimized parameters for each printer, the average error between designed and measured widths was 2.11 ± 1.26% with the DLP printer and 15.4 ± 2.57% with the 34.4 μm LCD printer. Printing with optimized conditions for a low-cost water-wash resin designed for LCD-SLA printers resulted in an average error of 2.53 ± 0.94% with the 34.4 μm LCD printer and 5.35 ± 4.49% with a 22 μm LCD printer. We characterized additional parameters including surface roughness, channel perpendicularity, and light intensity uniformity, and as an application of LCD-printed devices, we demonstrated consistent flow rates in capillaric circuits for self-regulated and self-powered delivery of multiple liquids. LCD printers are an inexpensive alternative for fabricating microfluidics, with minimal differences in fidelity and accuracy compared with a 40X more expensive DLP printer.

Identifiers

PMID39554414
PMCPMC11561756

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.