Evidence map›Paper›PMID 39554328›Full record

ArticleFood science & nutrition2024

Identification, quantification, and antidepressant-like evaluation of anthocyanin-rich extracts from different dietary berries.

Jun Wang, Jie Cheng, Ji-Xiao Zhu, Guang-Hui Xu, Wei-Feng Huang, Li-Tao Yi

Abstract read
In one paragraph

Article in Food science & nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Neuropsychiatric disease and treatment · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun WangDepartment of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University Xiamen People's Republic of China.
Jie ChengDepartment of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University Xiamen People's Republic of China.
Ji-Xiao ZhuResearch Center of Traditional Chinese Medicine Resources and Ethnic Medicine Jiangxi University of Chinese Medicine Nanchang People's Republic of China.
Guang-Hui XuXiamen Medicine Research Institute Xiamen People's Republic of China.
Wei-Feng HuangDepartment of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen People's Republic of China.
Li-Tao YiDepartment of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University Xiamen People's Republic of China.ORCID https://orcid.org/0000-0001-9052-8607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berries are highly valued for their rich phenolic content, particularly anthocyanins, which are known for their antioxidative properties and potential effectiveness against depression. This study identified and quantified anthocyanin profiles in blueberry, blackberry, black mulberry, and cranberry using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS), followed by in vivo evaluation of their antidepressant-like activities. Blueberry and black mulberry showed significant levels of cyanidin-3-galactoside and cyanidin. Acute supplementation with these berries decreased serum corticosterone levels and increased monoamine neurotransmitters, while chronic supplementation enhanced antioxidative activity and reduced neuroinflammation in the hippocampus of mice. These findings indicate that the neurochemical, antioxidative, and anti-inflammatory effects of blueberry and black mulberry mediate their therapeutic role against depression. Berries rich in cyanidin-3-galactoside and cyanidin may be valuable in developing functional foods, dietary supplements, and pharmacological formulations for mental health improvement.

Indexed as

anthocyaninantidepressantblack mulberryblueberry

Identifiers

PMID39554328
PMCPMC11561776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.