Evidence map›Paper›PMID 39554203›Full record

ArticleJAACAP open2024

Independent Contributions of Callous-Unemotional Behaviors and Quantitative Autistic Traits to Aggression in Early Childhood.

Kristen Lineback, Holly C Baer, Yi Zhang, David Hartenbach, W Roger Mills-Koonce, Michael T Willoughby, Anne L Glowinski, John N Constantino, Natasha Marrus

Abstract read
In one paragraph

Article in JAACAP open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristen LinebackWashington University School of Medicine in St. Louis, Missouri.
Holly C BaerWashington University School of Medicine in St. Louis, Missouri.
Yi ZhangWashington University School of Medicine in St. Louis, Missouri.
David HartenbachWashington University School of Medicine in St. Louis, Missouri.
W Roger Mills-KoonceUniversity of North Carolina at Chapel Hill, North Carolina.
Michael T WilloughbyRTI International, Raleigh, North Carolina.
Anne L GlowinskiWashington University School of Medicine in St. Louis, Missouri.
John N ConstantinoWashington University School of Medicine in St. Louis, Missouri.
Natasha MarrusWashington University School of Medicine in St. Louis, Missouri.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Callous-unemotional (CU) behaviors and quantitative autistic traits (QATs), heritable domains implicated in social development, are both associated with reduced prosocial behavior and increased aggression at their clinical extremes. However, they are hypothesized to contribute to aggression through separate mechanisms. This study tested whether CU behaviors and QATs exhibited distinct profiles of heritable influences as well as independent contributions to early childhood aggression in a general population sample with enhanced sensitivity to clarify these relationships. Method: Parents of 3- to 4-year-old epidemiologically representative twins ascertained from birth records (N = 113 pairs) completed questionnaires measuring CU behaviors, QATs, and aggression. Correlation coefficients indexed overlap across behaviors. Intraclass correlations were compared between monozygotic and dizygotic twins to characterize relative genetic and environmental influences. Generalized estimating equations tested contributions of CU subdomains, verified via factor analysis, and QATs to aggression. Results: Total CU scores strongly correlated with QATs ( Conclusion: Partially overlapping relations support distinct mechanisms whereby CU behaviors, in particular the callous factor, and QATs contribute to early aggression. In-depth social developmental assessment may enhance personalized intervention for aggression in early childhood. Diversity & Inclusion Statement: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure sex balance in the selection of non-human subjects. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science.

Indexed as

aggressionautistic traitscallous unemotionalearly childhoodtwin study

Identifiers

PMID39554203
PMCPMC11562414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.