ArticlebioRxiv : the preprint server for biology2024
Human Plasma Proteomic Profile of Clonal Hematopoiesis.
Abstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
49 authors.
Zhi YuBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-4810-3474
Amélie VrommanCardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Ngoc Quynh H NguyenDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Art SchuermansBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Thiago RentzCardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Shamsudheen K VellarikkalCardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Md Mesbah UddinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1846-0411
Abhishek NiroulaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Gabriel GriffinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael C HonigbergBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8630-5021
Amy E LinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Christopher J GibsonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel H KatzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Usman TahirDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Shi FangCardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Sara HaidermotaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Shriienidhie GaneshBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tajmara AntoineBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Joshua WeinstockDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7013-1899
Thomas R AustinCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Vasan S RamachandranDepartment of Medicine, School of Medicine, Boston University, Boston, MA, USA.
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Whitney HornsbyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Peter GanzDivision of Cardiology, Zuckerberg San Francisco General Hospital and Department of Medicine, University of California, San Francisco, CA, USA.
JoAnn E MansonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Bernhard HaringDepartment of Medicine III, Saarland University Hospital, Homburg, Germany.
Charles L KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alexander P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Joshua C BisDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Yuan-I MinDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Leslie A LangeDepartment of Medicine, Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Benjamin L EbertBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Bing YuDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Vijay G SankaranBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0044-443X
Alexander G BickDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Siddhartha JaiswalDepartment of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Robert E GersztenDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
NHLBI Trans-Omics for Precision Medicine
Peter LibbyCardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Rajat M GuptaCardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Pradeep NatarajanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8402-7435
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MTRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MAfrican Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7MPolygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS DP2 HL157540NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL133870NHLBI NIH HHS R01 HL134320NHLBI NIH HHS R01 HL134892NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL144483NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL151283NHLBI NIH HHS R01 HL153499NHLBI NIH HHS R01 HL159081NHLBI NIH HHS R01 HL163099NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS T32 HL007604NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK125782NIDDK NIH HHS U01 DK108809NIH HHS DP5 OD029586NIMHD NIH HHS HHSN268201800013INIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH123451
Abstract
Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 ancestrally diverse participants (3,881 with CHIP) from NHLBI TOPMed and UK Biobank with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2,917 proteins by Olink in UK Biobank), we identified 32 and 345 unique proteins from TOPMed and UK Biobank, respectively, associated with the most prevalent driver genes (
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.