Evidence map›Paper›PMID 39554166›Full record

ArticlebioRxiv : the preprint server for biology2024

Complex regulatory interactions at

Clarissa R Coveney, David Maridas, Hao Chen, Pushpanathan Muthuirulan, Zun Liu, Evelyn Jagoda, Siddharth Yarlagadda, Mohammadreza Movahhedi, Benedikt Proffen, Vicki Rosen and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Clarissa R CoveneyDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-8177-7353
David MaridasDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.
Hao ChenDepartment of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA.
Pushpanathan MuthuirulanDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Zun LiuDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Evelyn JagodaDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Siddharth YarlagaddaDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Mohammadreza MovahhediDepartment of Orthopaedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Benedikt ProffenDepartment of Orthopaedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Vicki RosenDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.
Ata M KiapourDepartment of Orthopaedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7742-5769
Terence D CapelliniDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Funding

Harvard Clinical and Translational Science CenterUM1TR004408 · NCATS · HARVARD MEDICAL SCHOOL · PI Lindsey Robert Baden, Lee Marshall Nadler · 2023 to 2026
$43.3M
Translational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Marie Demay · 2019 to 2026
$7.4M
Uncovering the Genetic Mechanisms Behind Joint-Specific OsteoarthritisR01AR070139 · NIAMS · HARVARD UNIVERSITY · PI CAPELLINI, TERENCE D · 2018 to 2022
$3.3M
NCATS NIH HHS UM1 TR004408NIAMS NIH HHS P30 AR075042NIAMS NIH HHS R01 AR070139
6 · The paper itself

Abstract

Our ability to pinpoint causal variants using GWAS is dependent on understanding the dynamic epigenomic and epistatic context of each associated locus. Being the best studied skeletal locus,

Identifiers

PMID39554166
PMCPMC11565913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.