Evidence map›Paper›PMID 39554163›Full record

ArticlebioRxiv : the preprint server for biology2024

Levetiracetam prevents Aβ

Nalini R Rao, Olivia DeGulis, Toshihiro Nomura, SeungEun Lee, Timothy J Hark, Justin C Dynes, Emily X Dexter, Maciej Dulewicz, Junyue Ge, Arun Upadhyay and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Nalini R RaoDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.ORCID 0000-0003-0913-5983
Olivia DeGulisDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Toshihiro NomuraDepartment of Neuroscience, Northwestern University Feinberg School of Medicine; Chicago, IL USA.ORCID 0000-0001-8786-831X
SeungEun LeeDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Timothy J HarkDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Justin C DynesDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Emily X DexterDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Maciej DulewiczDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg; Mölndal, Sweden.
Junyue GeDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg; Mölndal, Sweden.
Arun UpadhyayDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Eugenio F FornasieroDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0001-7643-4962
Robert VassarDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Jörg HanriederDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg; Mölndal, Sweden.
Anis ContractorDepartment of Neuroscience, Northwestern University Feinberg School of Medicine; Chicago, IL USA.
Jeffrey N SavasDepartment of Neurology, Northwestern University Feinberg School of Medicine; Chicago, IL USA.ORCID 0000-0002-8173-5580

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Steven Dyal Edland · 2019 to 2026
$34.9M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2019 to 2026
$34.5M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Walter K. Kremers · 2019 to 2026
$33.5M
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI NIKOLAOS K ROBAKIS · 2020 to 2026
$31.0M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Andrew Franklin Teich · 2020 to 2026
$30.1M
Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN · 2020 to 2026
$29.4M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV · 2020 to 2026
$29.0M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0M
NCI NIH HHS P30 CA060553NIA NIH HHS F31 AG079653NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG078796NIA NIH HHS R01 AG079280NIA NIH HHS R21 AG080705NIA NIH HHS RF1 AG022560NIA NIH HHS T32 AG020506NIA NIH HHS U24 AG072122NIH HHS S10 OD032464
6 · The paper itself

Abstract

In Alzheimer's disease (AD), amyloid-beta (Aβ) peptides are produced by proteolytic cleavage of the amyloid precursor protein (APP), which can occur during synaptic vesicle (SV) cycling at presynapses. Precisely how amyloidogenic APP processing may impair presynaptic proteostasis and how to therapeutically target this process remains poorly understood. Using

Indexed as

Alzheimer’s diseaseApp processingAβLevetiracetamproteomicssynapsesSynaptic vesicle

Identifiers

PMID39554163
PMCPMC11565754

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.