Evidence map›Paper›PMID 39554149›Full record

ArticlebioRxiv : the preprint server for biology2025

MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis.

Jonathon M Muncie-Vasic, Tanvi Sinha, Alexander P Clark, Emily F Brower, Jeffrey J Saucerman, Brian L Black, Benoit G Bruneau

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jonathon M Muncie-VasicORCID 0000-0002-7405-6213
Tanvi Sinha
Alexander P ClarkORCID 0000-0002-5200-6573
Emily F Brower
Jeffrey J Saucerman
Brian L Black
Benoit G Bruneau

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Early Cardiac ProgenitorsR01HL114948 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI Benoit Gaetan Bruneau · 2013 to 2026
$7.5M
Systems Pharmacology Model of Cardiac HypertrophyR01HL162925 · NHLBI · UNIVERSITY OF VIRGINIA · PI SAUCERMAN, JEFFREY J., WOLF, MATTHEW J · 2022 to 2025
$3.1M
Computational and Experimental Modeling of Cardiomyocyte ProliferationR01HL160665 · NHLBI · UNIVERSITY OF VIRGINIA · PI SAUCERMAN, JEFFREY J., VAN BERLO, JOHANNES (JOP) · 2022 to 2025
$2.8M
Gene regulatory networks for heart developmentR01HL155906 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN · 2021 to 2024
$2.4M
Defining the Cellular Morphogenic Behaviors that Shape the Developing HeartF32HL162450 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI MUNCIE-VASIC, JONATHON MICHAEL · 2022 to 2023
$137k
NHLBI NIH HHS F32 HL162450NHLBI NIH HHS R01 HL114948NHLBI NIH HHS R01 HL155906NHLBI NIH HHS R01 HL162925NHLBI NIH HHS T32 HL007284
6 · The paper itself

Abstract

The gene regulatory networks (GRNs) that control early heart formation are beginning to be understood, but lineage-specific GRNs remain largely undefined. We investigated networks controlled by the vital transcription factor MEF2C, with a time course of single-nucleus RNA- and ATAC-sequencing in wild-type and

Identifiers

PMID39554149
PMCPMC11566030

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.