Evidence map›Paper›PMID 39554145›Full record

ArticlebioRxiv : the preprint server for biology2024

Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.

Jessica J Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavania M Sherrill, Iain Colquhoun, Gabrielle Cadoux, Devyn Thorne, Johan Pääkkönen, Nathaniel F Schemmel, Joseph O'Connor and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jessica J PfannenstielDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0009-0003-0783-3208
Men Thi Hoai DuongFaculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Oulu, Finland.ORCID 0000-0002-1845-7186
Daniel CluffDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0001-7182-8903
Lavania M SherrillMcDaniel College Department of Chemistry, 2 College Hill, McDaniel College, Westminster, Maryland 21157, USA.
Iain ColquhounMcDaniel College Department of Chemistry, 2 College Hill, McDaniel College, Westminster, Maryland 21157, USA.
Gabrielle CadouxMcDaniel College Department of Chemistry, 2 College Hill, McDaniel College, Westminster, Maryland 21157, USA.
Devyn ThorneMcDaniel College Department of Chemistry, 2 College Hill, McDaniel College, Westminster, Maryland 21157, USA.
Johan PääkkönenFaculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Oulu, Finland.
Nathaniel F SchemmelDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Joseph O'ConnorDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Pradtahna SaenjamsaiDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Mei FengBiopharmaceutical Innovation & Optimization Center, University of Kansas, Lawrence, Kansas 66047, USA.
Michael J HagemanBiopharmaceutical Innovation & Optimization Center, University of Kansas, Lawrence, Kansas 66047, USA.ORCID 0000-0003-0824-6577
David K JohnsonMolecular Graphics and Modeling Laboratory and the Computational Chemical Biology Core, University of Kansas, Lawrence, Kansas, USA.
Anuradha RoyInfectious Disease Assay Development Laboratory/HTS, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0002-1057-1443
Lari LehtiöFaculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Oulu, Finland.ORCID 0000-0001-7250-832X
Dana V FerrarisMcDaniel College Department of Chemistry, 2 College Hill, McDaniel College, Westminster, Maryland 21157, USA.ORCID 0000-0001-5791-5939
Anthony R FehrDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0003-1560-1573

Funding

RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Determining mechanisms of innate immune modulation by ADP-ribosylationR35GM138029 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Anthony R Fehr · 2020 to 2026
$2.7M
NCATS NIH HHS UL1 TR002366NIGMS NIH HHS P20 GM113117NIGMS NIH HHS R35 GM138029
6 · The paper itself

Abstract

Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target proteins. SARS-CoV-2 Mac1 promotes virus replication in the presence of interferon (IFN) and blocks the production of IFN, though the mechanisms by which it mediates these functions remain unknown. Mac1 inhibitors could help elucidate these mechanisms and serve as therapeutic agents against CoV-induced diseases. We previously identified compound

Indexed as

ADP-ribosylationcoronavirusCOVID-19Murine Hepatitis Virusnsp3 macrodomainSARS-CoV2

Identifiers

PMID39554145
PMCPMC11565749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.