Evidence map›Paper›PMID 39554138›Full record

ArticlebioRxiv : the preprint server for biology2024

Metabolic regulation of RNA methylation by the m

Gunjan Sharma, Martin Gutierrez, Anthony E Jones, Amit Kumar Jaiswal, Zachary T Neeb, Amy Rios, Michelle L Thaxton, Tasha L Lin, Tiffany M Tran, Lyna E S Kabbani and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Gunjan SharmaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0003-3110-9239
Martin GutierrezDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA.
Anthony E JonesDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, United States.
Amit Kumar JaiswalDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
Zachary T NeebDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA.
Amy RiosDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, United States.
Michelle L ThaxtonDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
Tasha L LinDivision of Hematology and Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA.
Tiffany M TranDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
Lyna E S KabbaniDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA.
Alexander J RitterDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA.
Linsey StilesDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, United States.
Johanna Ten HoeveDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, United States.
Ajit S DivakaruniDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-2528-9651
Jeremy R SanfordDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA.ORCID 0000-0002-1131-1627
Dinesh S RaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZACK, JEROME A. · 1991 to 2018
$39.9M
UCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3M
Protein-RNA interactions in cancerR01CA264986 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Dinesh S. Rao, Jeremy Robert Sanford · 2021 to 2026
$3.7M
A postdoctoral training program for impactful careers in stem cell biologyT32HD108079 · NICHD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Bin Chen, CAMILLA FORSBERG · 2022 to 2026
$1.1M
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA264986NCI NIH HHS T32 CA009120NIAID NIH HHS P30 AI028697NICHD NIH HHS T32 HD108079
6 · The paper itself

Abstract

The interplay of RNA modifications - deposited by "writers", removed by "erasers" and identified by RNA binding proteins known as "readers" - forms the basis of the epitranscriptomic gene regulation hypothesis. Recent studies have identified the oncofetal RNA-binding protein IGF2BP3 as a "reader" of the N6-methyladenosine (m

Identifiers

PMID39554138
PMCPMC11565949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.